Maternal Occupational Physical Activity and Risk for Orofacial Clefts

Details

• Personal Author:
  Agopian AJ ; Delclos GL ; Herdt ML ; Kim J ; Langlois PH ; Lee L ; Symanski, Elaine ; Whitehead LW
• Description:
  Objectives: To perform a case-control study of maternal occupational physical activity and risk for orofacial clefts in Texas during 1999-2009. Methods: We used logistic regression to assess 14 measures of physical activity estimated from a job exposure matrix, using the maternal occupation reported on the birth certificate, among 887 children with cleft lip with or without cleft palate (CLP), 436 children with cleft palate only (CP), and 1932 controls. Results: After adjusting for several potential confounders, seven measures of physical activity (as a categorical and/or continuous variable) were significantly associated with CLP, CP, or both. Positive associations were seen for keeping balance, kneeling, standing, and walking/running (odds ratio 95% confidence interval range 1.0-1.9 for fourth versus first quartile). A significant positive trend was also seen for bending/twisting. Negative associations were seen for repetitive motion and sitting. Conclusions: Maternal occupational physical activity may be related to the etiology of orofacial clefts. [Description provided by NIOSH]
• Subjects:
  Case Reports Environmental Exposure Occupational Health Pregnancy Risk Assessment Risk Factors Safety Women
• Keywords:
  Author Keywords: Cleft Lip With Or Without Cleft Palate Birth Defects Case Studies Children Etiology Exposure Levels Humans JEM Job Analysis Job Exposure Matrix Occupation Occupations Physical Activity Physical Exercise Physical Stress Regression Analysis Risk Factors

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  60
• Issue:
  7
• NIOSHTIC Number:
  nn:20052719
• Citation:
  Am J Ind Med 2017 Jul; 60(7):627-634
• Contact Point Address:
  A. J. Agopian, PhD, University of Texas Health Science Center at Houston (UTHealth) School of Public Health, 1200 Herman Pressler, Houston, TX 77030
• Email:
  a.j.agopian@uth.tmc.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:020b8c1c41cf06d5e4c5bd1c8abe48b3be217f1cd996e66f5be524fc8c39dbdaaa727843f6fa0219b9f970e163f3257c9e170541b082591987bf5b2f2e875b9a
• Download URL:
  https://stacks.cdc.gov/view/cdc/212201/cdc_212201_DS1.pdf
• File Type:
  [PDF - 136.95 KB ]