Immunoregulatory Responses in Trimellitic Anhydride Occupational Sensitization

Details

• Personal Author:
  Ghosh D
• Description:
  The specific aims for this project are as follows: Specific Aim 1: TMA-exposure levels: Pumped filter/sorbent method. Air samples collected on TENAX sorbent are converted from TM Anhydride to TM Acid, which is then quantitated by HPLC attached to UV detector; Study population: Age, gender, ethnicity, smoking history; Exposure and clinical data: spirometry data, duration of TMA exposure (in months), level of TMA exposure, total IgE, TMA specific skin testing, TMA specific IgG, IgG4 and IgE. Specific Aim 2: To identify T-cell activation patterns (TH1/TH2 balance and Treg activation) in TMA exposed/non-sensitized, exposed/IgG sensitized, exposed/IgG and IgE sensitized and non-exposed/non-sensitized workers; We have identified workers who are TMA exposed/non-sensitized (n=10), TMA exposed/IgG sensitized (n=10), TMA exposed/IgG and IgE sensitized (n=10) and TMA non-exposed/non-sensitized workers (n=10) for clinico-immunological study (specific aim-2). [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Demography Hypersensitivity Immune System Occupational Health Phthalic Anhydrides Respiratory System Safety
• Keywords:
  Airborne Particles Demographic Characteristics Exposure Assessment Immune Reaction Immunoglobulins Respiratory Irritants Sensitization Trimellitic Anhydride
• Publisher:
  University of Cincinnati
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-12
• NIOSHTIC Number:
  nn:20052678
• Citation:
  10th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 1-2, 2009, Cincinnati, Ohio. Cincinnati, OH: University of Cincinnati, 2009 Oct; :1-12
• CAS Registry Number:
  Trimellitic anhydride (CAS RN 552-30-7)
• Federal Fiscal Year:
  2010
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  10th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 1-2, 2009, Cincinnati, Ohio
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f6807b7029d8f51a4def2503b40b8fadd3f50a1c677bef014f8fda05039618d8beb4510347469db6810fe7bb46cf4ddd41b7ad3313ad7b6974460fb434f5bbe7
• Download URL:
  https://stacks.cdc.gov/view/cdc/212177/cdc_212177_DS1.pdf
• File Type:
  [PDF - 343.41 KB ]