Identification of Immunologic and Genetic Biomarkers for TMA Sensitization

Details

• Personal Author:
  Ghosh D
• Description:
  In summary, we have identified relevant genes and pathways differentially expressed between free TMA exposure and TMA-HSA allergen exposure to plasmacytoid Dendritic cells, which is a key cell type to sense environmental allergens and irritants. This study strongly suggests there are divergent mechanistic pathways for irritant vs. antibody-mediated immunologic responses for TMA exposure. This is an important starting point to determine if these DEG are useful biomarkers for differentiating workers at risk for TMA- induced irritant or allergenic responses who have continuous or intermittent exposures. Contribute to better diagnosis and management of occupation health hazard caused by TMA exposure. [Description provided by NIOSH]
• Subjects:
  Biomarkers Hypersensitivity Immune System Irritants Occupational Health Phthalic Anhydrides Safety
• Keywords:
  Allergens Immune Reaction Paint Manufacturing Industry Plastics Industry Sensitization Trimellitic Anhydride
• Publisher:
  University of Cincinnati
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-17
• NIOSHTIC Number:
  nn:20052519
• Citation:
  16th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 8-9, 2015, Cincinnati, Ohio. Cincinnati, OH: University of Cincinnati, 2015 Oct; :1-17
• CAS Registry Number:
  Trimellitic anhydride (CAS RN 552-30-7)
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  16th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 8-9, 2015, Cincinnati, Ohio
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ca5d0a78eb49f5ca9babfed6c8f5c6aa2d47eb8161c0fd79c51346883c0141eec3bea28b7da5fa0346505a9e0093626cd88a4ccbf99f3fe2f82a5a9038db6038
• Download URL:
  https://stacks.cdc.gov/view/cdc/212032/cdc_212032_DS1.pdf
• File Type:
  [PDF - 487.50 KB ]