Enhanced Exposure Assessment and Genome-Wide DNA Methylation in World Trade Center Disaster Responders

Details

• Personal Author:
  Boffetta P ; Georgopoulos P ; Hashim D ; Kuan P-F ; Luft BJ ; Mi Z
• Description:
  DNA methylation has emerged as a promising target linking environmental exposures and cancer. The World Trade Center (WTC) responders sustained exposures to potential carcinogens, resulting in an increased risk of cancer. Previous studies of cancer risk in WTC-exposed responders were limited by the deficiency in quantitative and individual information on exposure to carcinogens. The current study introduces a new exposure-ranking index (ERI) for estimating cancer-related acute and chronic exposures, which aimed to improve the ability of future analyses to estimate cancer risk. An epigenome-wide association study based on DNA methylation and a weighted gene co-expression network analysis were carried out to identify cytosine-phosphate-guanosine (CpG) sites, modules of correlated CpG sites, and biological pathways associated with the new ERI. Methylation was profiled on blood samples using Illumina 450K Beadchip. No significant epigenome-wide association was found for ERI at a false discovery rate of 0.05. Several cancer-related pathways emerged in pathway analyses for the top ranking genes from epigenome-wide association study as well as enriched module from the weighted gene co-expression network analysis. The current study was the first DNA methylation study that aimed to identify methylation signature for cancer-related exposure in the WTC population. No CpG sites survived multiple testings adjustment. However, enriched gene sets involved in cancer, were identified in both acute and chronic ERIs, supporting the view that multiple genes play a role in this complex exposure. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Carcinogens Environmental Exposure Genetics Hematologic Tests Neoplasms Occupational Health Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

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• Keywords:
  Biological Agents Blood Samples Cancer Deoxyribonucleic Acids DNA Environmental Exposure Exposure Limits Genes Risk Factors World Trade Center WTC

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• ISSN:
  0959-8278
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  225-233
• Volume:
  28
• Issue:
  3
• NIOSHTIC Number:
  nn:20052331
• Citation:
  Eur J Cancer Prev 2019 May; 28(3):225-233
• Contact Point Address:
  Paolo Boffetta, MD, MPH, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1130, New York NY 10029, USA
• Email:
  paolo.boffetta@mssm.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  Icahan School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20150701
• Source Full Name:
  European Journal of Cancer Prevention
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0197743fc2734b67c7556c6ab65ccdca7090a98a643212d6a5cea7f75084be7f4fef299c94aafb8db356a5b8fbb5d811df9ffc1879dc91909865acd106a04876
• Download URL:
  https://stacks.cdc.gov/view/cdc/211875/cdc_211875_DS1.pdf
• File Type:
  [PDF - 211.69 KB ]