Parental Occupational Pesticide Exposure and Nonsyndromic Orofacial Clefts

Details

• Personal Author:
  Bell EM ; Burns TL ; Cao Y ; Conway K ; Langlois P ; Rocheleau C ; Romitti PA ; Stewart P ; Suhl J
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  Nonsyndromic orofacial clefts are common birth defects. Reported risks for orofacial clefts associated with parental occupational pesticide exposure are mixed. To examine the role of parental pesticide exposure in OFC development in offspring, this study compared population-based case-control data for parental occupational exposures to insecticides, herbicides, and fungicides, alone or in combinations, during maternal (one month before through three months after conception) and paternal (three months before through three months after conception) critical exposure periods between orofacial cleft cases and unaffected controls. Multivariable logistic regression was used to estimate odds ratios, adjusted for relevant covariables, and 95% confidence intervals for any (yes, no) and cumulative (none, low [/=median exposure level in controls]) occupational pesticide exposures and cleft lip +/- cleft palate and cleft palate. Compared to controls, associations for cleft lip +/- cleft palate tended to be near unity for maternal or paternal occupational pesticide exposures, except for low paternal exposure to any pesticide, which produced a statistically significant inverse association with this subtype. Associations for cleft palate tended to be near unity for maternal exposures and mostly positive, but non-significant, for paternal exposures; a significant positive association was observed between paternal low exposure to insecticide+herbicide+fungicide and cleft palate. Combined parental exposure produced non-significant associations near or below unity for all orofacial cleft cases combined and cleft lip +/- cleft palate and positive, but non-significant, associations for cleft palate. This study observed associations mostly near unity between maternal occupational pesticide exposure and orofacial clefts. Associations for paternal occupational pesticide exposures were mostly near or below unity for cleft lip +/- cleft palate, and mostly positive for cleft palate. However, due to the limitations of this study, these subtype-specific results should be interpreted cautiously. Future research examining parental occupational pesticide exposure and orofacial clefts should attempt to improve exposure assessment and increase sample size to better facilitate risk estimation. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Fungi Fungicide, Industrial Herbicides Insecticides Men Occupational Health Pregnancy Risk Assessment Risk Factors Safety Women Workplace

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• Keywords:
  Author Keywords: Cleft Lip Birth Defects Children Cleft Palate Exposure Levels Fungicides Humans Pesticides Pesticides And Agricultural Chemicals Risk Factors Work Environment Workers

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• ISSN:
  1545-9624
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 7 ; Texas ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• Issue:
  9
• NIOSHTIC Number:
  nn:20052105
• Citation:
  J Occup Environ Hyg 2018 Sep; 15(9):641-653
• Contact Point Address:
  Paul A. Romitti, Department of Epidemiology, College of Public Health, University of Iowa, 145 N Riverside Dr, S416 CPHB, Iowa City, IA 52242
• Email:
  paul-romitti@uiowa.edu
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Hygiene
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:447b5d294b258078b3f15109109ed577c66e717f6d00c121f49ab1779729f5da7d36c32b5ddab2d67a0be402e8f5c03466041dfe61d9fb10e78403a3b90419e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/211696/cdc_211696_DS1.pdf
• File Type:
  [PDF - 1.65 MB ]