Low-Dose Agrochemicals and Lawn-Care Pesticides Induce Developmental Toxicity in Murine Preimplantation Embryos

Details

• Personal Author:
  Berg RL ; Ellis TM ; Greenlee AR
• Description:
  Occupational exposures to pesticides may increase parental risk of infertility and adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, and congenital anomalies. Less is known about residential use of pesticides and the risks they pose to reproduction and development. In the present study we evaluate environmentally relevant, low-dose exposures to agrochemicals and lawn-care pesticides for their direct effects on mouse preimplantation embryo development, a period corresponding to the first 5-7 days after human conception. Agents tested were those commonly used in the upper midwestern United States, including six herbicides [atrazine, dicamba, metolachlor, 2,4-dichlorophenoxyacetic acid (2,4-D)], pendimethalin, and mecoprop), three insecticides (chlorpyrifos, terbufos, and permethrin), two fungicides (chlorothalonil and mancozeb), a desiccant (diquat), and a fertilizer (ammonium nitrate). Groups of 20-25 embryos were incubated 96 hr in vitro with either individual chemicals or mixtures of chemicals simulating exposures encountered by handling pesticides, inhaling drift, or ingesting contaminated groundwater. Incubating embryos with individual pesticides increased the percentage of apoptosis (cell death) for 11 of 13 chemicals (p
• Subjects:
  Agriculture Environmental Exposure Fungi Fungicide, Industrial Herbicides Insecticides Occupational Exposure Occupational Health Pregnancy Risk Assessment Risk Factors Safety

  More +
• Keywords:
  Agricultural-industry Author Keywords: Apoptosis Embryo Environmental-exposure Fungicides In-vitro-studies Occupational-exposure Pesticide Mixtures Pesticides Preimplantation Development Reference Dose Risk-analysis Risk-factors

  More +
• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  112
• Issue:
  6
• NIOSHTIC Number:
  nn:20027492
• Citation:
  Environ Health Perspect 2004 May; 112(6):703-709
• Contact Point Address:
  A.R. Greenlee, Reproductive Toxicology Laboratory, Marshfield Clinic Research Foundation, 1000 North Oak Ave., Marshfield, WI 54449 USA
• Email:
  anne@mcrf.mfldclin.edu
• CAS Registry Number:
  (2,4-Dichlorophenoxy)acetic acid (CAS RN 94-75-7) ; Ammonium nitrate (CAS RN 6484-52-2) ; Atrazine (CAS RN 1912-24-9) ; Chlorothalonil (CAS RN 1897-45-6) ; Chlorpyrifos (CAS RN 2921-88-2) ; Dicamba (CAS RN 1918-00-9) ; Mancozeb (CAS RN 8018-01-7) ; Mecoprop (CAS RN 93-65-2) ; Permethrin (CAS RN 52645-53-1)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Marshfield Medical Research & Education Foundation, Marshfield, Wisconsin
• Peer Reviewed:
  True
• Start Date:
  19970930
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e08c22d764f5f44bd52b44f774bc6bc2967ace1286d1107dbdfbc2dc080fc2e723137db8cdd4d85cecf58e9a5737aa29bd89ee7eae22dbb3881449bd591d5d0e
• Download URL:
  https://stacks.cdc.gov/view/cdc/197586/cdc_197586_DS1.pdf
• File Type:
  [PDF - 378.99 KB ]