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Field Evaluation of Onsite Near Real-Time Monitors for Surface Contamination by 5-Fluorouracil

Public Domain


Details

  • Personal Author:
  • Description:
    Objectives: In order to produce near real-time onsite results to detect surface contamination by antineoplastic drugs, the National Institute for Occupational Safety and Health developed monitors for 5-fluorouracil, which use surface wiping and lateral flow immunoassay for measurement. The monitors were tested in the laboratory to assess the sensitivity of detection on laboratory-produced contaminated surfaces. A field evaluation to assess the capability of the monitors to make measurements in healthcare workplaces was carried out in collaboration with a medical device company and the results are presented in this report. Methods: The 5-fluorouracil monitor was evaluated in areas where oncology drugs were prepared and administered to patients at five different hospitals. The levels of contamination measured with the monitors were compared to levels measured with liquid chromatography-tandem mass spectrometry. Results: The 5-fluorouracil values measured with the liquid chromatography-tandem mass spectrometry ranged from 0 to over 200,000?ng/100?cm2. Measurements by the 5-fluorouracil monitors in the range 10-100?ng/100?cm2 correlated with the liquid chromatography-tandem mass spectrometry. Receiver operating characteristic curves developed for the data indicated that a positive limit of 22 ng/100 cm2 would give an acceptable level of false-positives while retaining most true-positive samples. If the liquid chromatography-tandem mass spectrometry measured greater than 100 ng/100 cm2, then the monitors also measured levels greater than 100 ng/100 cm2 for the majority of samples. Conclusion: The data indicate that there are many areas in hospitals that are contaminated with 5-fluorouracil and the monitors will be useful in identifying this contamination. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1078-1552
  • Document Type:
    Text
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Division:
    DART - Division of Applied Research and Technology
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    25
  • Issue:
    5
  • NIOSHTIC Number:
    nn:20051934
  • Citation:
    J Oncol Pharm Pract 2019 Jul; 25(5):1152-1159
  • Contact Point Address:
    Jerome P Smith, NIOSH, 1090 Tusculum Ave, Mail Stop C-26, Cincinnati, OH 45226, USA
  • Email:
    jps3@cdc.gov
  • Federal Fiscal Year:
    2019
  • NORA Priority Area:
    Construction
  • Peer Reviewed:
    True
  • Source Full Name:
    Journal of Oncology Pharmacy Practice
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:b4c4a0dcf28e2fdfda80edf82cb20bd627dd67b83acd0d382cfc5ebe0d1116cce1529219bdfc90089d6264aa80c8552566ab30d2d28c608028e2395a4f4e194b
  • Download URL:
  • File Type:
    Filetype[PDF - 453.14 KB ]
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