Post-Traumatic Stress Disorder and Cardiovascular Diseases: A Cohort Study of Men and Women Involved in Cleaning the Debris of the World Trade Center Complex

Details

• Personal Author:
  Flory J ; Laskaris Z ; Morabia A ; Mora-McLaughlin C ; Remch M
• Description:
  BACKGROUND: We sought to determine whether post-traumatic stress disorder (PTSD) is a risk factor for myocardial infarction (MI) and stroke, beyond the expected effects from recognized cardiovascular risk factors and depression. METHODS AND RESULTS: World Trade Center-Heart is an observational prospective cohort study of 6481 blue-collar first responders nested within the World Trade Center Health Program in New York City. Baseline measures in 2012 and 2013 included blood pressure, weight and height, and blood lipids. PTSD, depression, smoking, and dust exposure during the 2001 cleanup were self-reported. During the 4-year follow-up, outcomes were assessed through (1) interview-based incident, nonfatal MI, and stroke, validated in medical charts (n=118); and (2) hospitalizations for MI and stroke for New York city and state residents (n=180). Prevalence of PTSD was 19.9% in men and 25.9% in women, that is, at least twice that of the general population. Cumulative incidence of MI or stroke was consistently larger for men or women with PTSD across follow-up. Adjusted hazard ratios (HRs) were 2.22 (95% confidence interval [CI], 1.30-3.82) for MI and 2.51 (95% CI, 1.39-4.57) for stroke. For pooled MI and stroke, adjusted HRs were 2.35 (95% CI, 1.57-3.52) in all and 1.88 (95% CI, 1.01--3.49) in men free of depression. Using hospitalization registry data, adjusted HRs were 2.17 (95% CI, 1.41-3.32) for MI; 3.01 (95% CI, 1.84-4.93) for stroke; and for pooled MI and stroke, the adjusted HR was 2.40 (95% CI, 1.73-3.34) in all, HR was 2.44 (95% CI, 1.05-5.55) in women, and adjusted HR was 2.27 (95% CI, 1.41-3.67) in men free of depression. World Trade Center dust exposure had no effect. CONCLUSIONS: This cohort study confirms that PTSD is a risk factor for MI and stroke of similar magnitude in men and women, independent of depression. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Mental Health Nervous System Occupational Health Safety September 11 Terrorist Attacks Stress, Psychological
• Keywords:
  Author Keywords: Air Pollution Cardiovascular Disease Cardiovascular System Cardiovascular System Disease Cardiovascular System Disorders Depression Disasters Heart Heart Attacks Heart Disease Humans Mental Health Mental Stress Myocardial Disorders Myocardial Infarction Post-traumatic Post-traumatic Stress Disorder Psychological Effects Psychological Reactions Psychological Responses Psychological Stress PTSD Stress Disorders Stroke World Trade Center WTC

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• ISSN:
  1941-7705
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; New York ; North Carolina ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• Issue:
  7
• NIOSHTIC Number:
  nn:20051893
• Citation:
  Circ Cardiovasc Qual Outcomes 2018 Jul; 11(7):e004572
• Contact Point Address:
  Alfredo Morabia, MD, PhD Department of Epidemiology, Mailman School of Public Health, Columbia University, W 168th St, New York, NY 10032
• Email:
  am52@cumc.columbia.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  Queens College, Flushing, New York
• Peer Reviewed:
  True
• Start Date:
  20140701
• Source Full Name:
  Circulation: Cardiovascular Quality and Outcomes
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6897dcf266e1f54f59bceebd63e771d160ce1b2e61de718732a6d21b7ccaca75e00f73c5bef200d405fae0522c2787213d2341cd756b68458720db548a2a49e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/211573/cdc_211573_DS1.pdf
• File Type:
  [PDF - 1.43 MB ]