The Role of Lymphocyte Proliferation Tests in Assessing Occupational Sensitization and Disease

Details

• Personal Author:
  Hines SE ; Maier LA ; Pacheco, Karin
• Description:
  Lymphocyte proliferation testing (LPT) is used in diagnosing occupationally acquired delayed-type hypersensitivity. It has been used in beryllium-health effects, and its role is expanding in metal allergy. It may find application in diagnosis of other sensitizers. Recent findings: Use of the beryllium LPT (BeLPT) in medical surveillance identifies beryllium sensitization at low exposure with chronic beryllium disease (CBD) that leads to physiologic impairment and need for immunosuppressive medications. New studies indicate that both beryllium exposure and genetic variation are associated with increased risk of CBD. Borderline positive BeLPTs warrant inclusion into diagnostic algorithms. Furthermore, use of LPTs to diagnose metal allergy is being proposed in diagnosis of chromium allergy and hypersensitivity to surgical implants. New occupational sensitizers continue to be identified including metalworking fluids, the sterilizing agent ortho-phthalaldehyde and the solvent para-chlorobenzotrifluoride. Use of LPT in occupational surveillance to these agents and other known sensitizers may play expanding roles. Summary: Lymphocyte proliferation testing serves a valuable role in diagnosing occupational sensitization, as demonstrated with beryllium-health effects, as cases continue to be found at low exposure levels. The use of LPTs in diagnosing contact allergy is expanding, and new applications may be identified in human and animal studies. [Description provided by NIOSH]
• Subjects:
  Antigens Beryllium Blood Diagnosis Environmental Exposure Genetics Health Care Facilities Workforce And Services Hematologic Tests Hypersensitivity Immune System Occupational Health Safety

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• Keywords:
  Allergens Allergic Reactions Author Keywords: Beryllium Beryllium Compounds Beryllium Disease Blood Tests Cell Signaling Chronic Beryllium Disease Clinical Tests Contact Allergies Contact Allergy Diagnostic Techniques Diagnostic Tests Exposure Levels Immune System Lymphatic System Lymphocyte Proliferation Test Lymphocytes Medical Monitoring Occupational Surveillance Physiological Effects Sensitization Sensitizers Surveillance

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• ISSN:
  1528-4050
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Maryland ; OSHA Region 3 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  102-110
• Volume:
  12
• Issue:
  2
• NIOSHTIC Number:
  nn:20051636
• Citation:
  Curr Opin Allergy Clin Immunol 2012 Apr; 12(2):102-110
• Contact Point Address:
  Stella E. Hines, MD, MSPH, Assistant Professor, Occupational Health Program, Department of Medicine,The University of Maryland School of Medicine, 11 South Paca Street, Second Floor, Baltimore, MD 21201, USA
• Email:
  shines@medicine.umaryland.edu
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Colorado, Denver
• Peer Reviewed:
  True
• Start Date:
  20070701
• Source Full Name:
  Current Opinion in Allergy and Clinical Immunology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b5ab866d843c16a7d3f6f09f2bd58e1a7e80500600780f7a2fdca9b4a1269d00cb2a84a847797016db386afe6e9fa1f429c793db045c2a5acb8a048eb86ab913
• Download URL:
  https://stacks.cdc.gov/view/cdc/211493/cdc_211493_DS1.pdf
• File Type:
  [PDF - 271.48 KB ]