Research to practice implications of high-risk genotypes for beryllium sensitization and disease

Details

• Personal Author:
  Fechter-Leggett, Ethan D. ; Kreiss, Kathleen ; McCanlies EC ; Schuler, Christine R. ; Weston A
• Description:
  Objective: Beryllium workers may better understand their genetic susceptibility to chronic beryllium disease (CBD) expressed as population-based prevalence, rather than odds ratios from case-control studies. Methods: We calculated CBD prevalences from allele-specific DNA sequences of 853 workers for Human Leukocyte Antigen (HLA)-DPB1 genotypes and groups characterized by number of E69-containing alleles and by calculated surface electronegativity of HLA-DPB1. Results: Of 18 groups of at least 10 workers with specific genotypes, CBD prevalence was highest, 72.7%, for the HLA-DPB1*02:01:02/DPB1*17:01 genotype. Population-based grouped genotypes with two E69 alleles wherein one allele had -9 surface charge had a beryllium sensitization (BeS) of 52.6% and a CBD prevalence of 42.1%. Conclusions: The high CBD and BeS prevalences associated with -9-charged E69 alleles and two E69s suggest that workers may benefit from knowing their genetic susceptibility in deciding whether to avoid future beryllium exposure. [Description provided by NIOSH]
• Subjects:
  Antigens Beryllium Environmental Exposure Genetics Metals Occupational Health Risk Assessment Risk Factors Safety Workplace
• Keywords:
  Beryllium Compounds Beryllium Disease Exposure Levels Genotype Metal Compounds Metallic Compounds Risk Factors Statistical Analysis Work Environment Workers
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division ; DSR - Division of Safety Research
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  58
• Issue:
  9
• NIOSHTIC Number:
  nn:20048470
• Citation:
  J Occup Environ Med 2016 Sep; 58(9):855-860
• Contact Point Address:
  Ethan D. Fechter-Leggett, DVM, Respiratory Health Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  iun8@cdc.gov
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5cbc1af67d50060dcf4b8ba78ef160eb63304897e8927257578c1816d73dea66896d41d638f4d3b2952454e982ff0b193add7ada950d27a97d0c9567baffed29
• Download URL:
  https://stacks.cdc.gov/view/cdc/203219/cdc_203219_DS1.pdf
• File Type:
  [PDF - 295.21 KB ]