The Systemic Toxicity of Heavy Metal Mixtures in Rats

Details

• Personal Author:
  Aldinger, Jeffrey A. ; Barber T ; Ding M ; Gu Y ; Hua Q ; Kenston SSF ; Kong L ; Li Z ; Lin X ; Song X ; Su H ; Wang Y ; Zhao J
• Description:
  To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose of heavy metal mixtures (HMMs). The eight most common detectable heavy metals in Ningbo area are zinc (Zn), copper (Cu), manganese (Mn), chromium (Cr), nickel (Ni), cadmium (Cd), lead (Pb) and mercury (Hg). In this study, mixtures of these eight heavy metals were prepared using the compounds zinc sulfate heptahydrate, cupric sulfate, manganese dichloride, potassium dichromate, nickel dichloride, cadmium dichloride, lead acetate, and methyl mercury chloride with ion mass proportions of 1070.0, 312.6, 173.1, 82.6, 30.0, 13.3, 6.6, and 1.0, respectively. The rats were randomly divided into four groups. Beside the control group, each rat received a corresponding dose of HMMs 215, 464 or 1000 mg per kg body weight (bwt), respectively. The rats were observed for 4 weeks. During the last week of observation, the Morris water maze test was used to investigate spatial learning and memory in the treated rats. The rats were exsanguinated under complete chloral hydrate anesthesia and organ coefficients were measured. Biochemical tests of blood and serum samples were carried out. The results showed abnormalities in the hematological system, decreased renal function, hepatic injury and disturbances in the electrolyte balance of the rats treated with a high dose of HMMs. Death of some rats was also observed. This paper analyzed how a one-time high dose oral administration of HMMs induced systemic toxicity. [Description provided by NIOSH]
• Subjects:
  Animals Biochemistry Blood Body Weight Cadmium Chromium Copper Hematologic Tests Laboratories Lead Manganese Mercury Metals Metals, Heavy Nickel Occupational Health Risk Assessment Risk Factors Safety

  More +
• Keywords:
  Biochemical Tests Body Weight Cadmium Compounds Chromium Compounds Copper Compounds Electrolytes Exposure Limits Health Effects Heavy Metals Hematology Laboratory Animals Lead Compounds Manganese Compounds Mercury Compounds Nickel Compounds Risk Factors Sampling Zinc Zinc And Compounds

  More +
• ISSN:
  2045-452X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  396-407
• Volume:
  7
• Issue:
  3
• NIOSHTIC Number:
  nn:20051628
• Citation:
  Toxicol Res 2018 May; 7(3):396-407
• Contact Point Address:
  Jinshun Zhao, Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang Province, 315211, People's Republic of China
• Email:
  zhaojinshun@nbu.edu.cn
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Cadmium chloride (CAS RN 10108-64-2) ; Chromium (CAS RN 7440-47-3) ; Copper (CAS RN 7440-50-8) ; Lead (CAS RN 7439-92-1) ; Lead diacetate (CAS RN 301-04-2) ; Manganese (CAS RN 7439-96-5) ; Mercury (CAS RN 7439-97-6) ; Nickel (CAS RN 7440-02-0) ; Potassium dichromate (CAS RN 7778-50-9) ; Zinc (CAS RN 7440-66-6) ; Zinc sulfate heptahydrate (CAS RN 7446-20-0)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:19d5abe7fe6316ed22aa25d92de93bd9c483c272c50e61b8341016d4c1c355258a2ed49547b59de1873f51c2a03b77e098327321365c47a0b3f0dec78f7fea86
• Download URL:
  https://stacks.cdc.gov/view/cdc/211490/cdc_211490_DS1.pdf
• File Type:
  [PDF - 1.12 MB ]