Dose-Response Relationships Between Internally-Deposited Uranium and Select Health Outcomes in Gaseous Diffusion Plant Workers, 1948–2011

Details

• Personal Author:
  Anderson, Jeri L. ; Bertke SJ ; Tollerud DJ ; Yiin JH
• Description:
  Objective: To examine dose-response relationships between internal uranium exposures and select outcomes among a cohort of uranium enrichment workers. Methods: Cox regression was conducted to examine associations between selected health outcomes and cumulative internal uranium with consideration for external ionizing radiation, work-related medical X-rays and contaminant radionuclides technetium (99Tc) and plutonium (239Pu) as potential confounders. Results: Elevated andmonotonically increasing mortality risks were observed for kidney cancer, chronic renal diseases, and multiple myeloma, and the association with internal uranium absorbed organ dose was statistically significant for multiple myeloma. Adjustment for potential confounders had minimal impact on the risk estimates. Conclusion: Kidney cancer, chronic renal disease, and multiple myeloma mortality risks were elevated with increasing internal uranium absorbed organ dose. The findings add to evidence of an association between internal exposure to uranium and cancer. Future investigation includes a study of cancer incidence in this cohort. [Description provided by NIOSH]
• Subjects:
  Mortality Neoplasms Occupational Health Radiation Safety
• Keywords:
  Author Keywords: Absorbed Organ Doses Cancer Rates Dose-response Dose Response Gaseous Diffusion Kidney Disorders Mortality Rates Radionuclides Uranium Uranium Enrichment
• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Kentucky ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  61
• Issue:
  7
• NIOSHTIC Number:
  nn:20051552
• Citation:
  Am J Ind Med 2018 Jul; 61(7):605-614
• Contact Point Address:
  James H. Yiin, PhD, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1090 Tusculum Ave, MailStop R-15, Cincinnati, OH 45226
• Email:
  jcy5@cdc.gov
• CAS Registry Number:
  Uranium (CAS RN 7440-61-1)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:237dcc12eb239f236e8c5a1350c245b57918f1dd115a6a2b595006197543b0bea3e7e728d44f2335919eec2976fe77e9d5c1b8aee8dec375e571b3abbb7ae68f
• Download URL:
  https://stacks.cdc.gov/view/cdc/211449/cdc_211449_DS1.pdf
• File Type:
  [PDF - 588.09 KB ]