Mortality in a combined cohort of uranium enrichment workers

Details

• Personal Author:
  Anderson, Jeri L. ; Bertke SJ ; Chen P-H ; Daniels, Robert D. ; Fleming DA ; Tollerud DJ ; Tseng C-Y ; Waters, Kathy M. ; Yiin JH
• Description:
  Objective: To examine the patterns of cause-specific mortality and relationship between internal exposure to uranium and specific causes in a pooled cohort of 29,303 workers employed at three former uranium enrichment facilities in the United States with follow-up through 2011. Methods: Cause-specific standardized mortality ratios (SMRs) for the full cohort were calculated with the U.S. population as referent. Internal comparison of the dose-response relation between selected outcomes and estimated organ doses was evaluated using regression models. Results: External comparison with the U.S. population showed significantly lower SMRs in most diseases in the pooled cohort. Internal comparison showed positive associations of absorbed organ doses with multiple myeloma, and to a lesser degree with kidney cancer. Conclusion: In general, these gaseous diffusion plant workers had significantly lower SMRs than the U.S. population. The internal comparison however, showed associations between internal organ doses and diseases associated with uranium exposure in previous studies. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Morbidity Mortality Neoplasms Occupational Health Radiation Risk Assessment Risk Factors Safety Workplace
• Keywords:
  Absorbed Organ Doses Author Keywords: Uranium Enrichment Cancer Diseases Dose Response Exposure-response Exposure Levels Gaseous Diffusion Kidneys Models Morbidity Rates Mortality Rates Risk Factors Standardized Mortality Ratios Uranium Uranium Compounds Work Environment Workers

  More +
• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Kentucky ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  96-108
• Volume:
  60
• Issue:
  1
• NIOSHTIC Number:
  nn:20048819
• Citation:
  Am J Ind Med 2017 Jan; 60(1):96-108
• Contact Point Address:
  James H. Yiin, PhD, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1090 Tusculum Ave, MailStop R-15, Cincinnati, OH
• Email:
  jcy5@cdc.gov
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5c5e36bdffcfd15126648d87844e90c77da16957c3e0e49d2c7559afc6b0ee4bd996f15460da9a4a94b44fe4d247dd00aac8fdc32b788747c95edf026c7691e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/203450/cdc_203450_DS1.pdf
• File Type:
  [PDF - 137.61 KB ]