Respirable Uranyl-Vanadate-Containing Particulate Matter Derived from a Legacy Uranium Mine Site Exhibits Potentiated Cardiopulmonary Toxicity

Details

• Personal Author:
  Ali A-M ; Avasarala S ; Brearley A ; Campen MJ ; Cerrato JM ; Erdely A ; Harmon M ; Herbert G ; Kodali V ; Kunda NK ; Lin Y ; Muttil P ; Ordonez Suarez Y ; Sanchez B ; Shoeb M ; Shuey C ; Tyler CR ; Wheeler A ; Zychowski KE
• Description:
  Exposure to windblown particulate matter (PM) arising from legacy uranium (U) mine sites in the Navajo Nation may pose a human health hazard due to their potentially high metal content, including U and vanadium (V). To assess the toxic impact of PM derived from Claim 28 (a priority U mine) compared with background PM, and consider the putative role of metal species U and V. Two representative sediment samples from Navajo Nation sites (Background PM and Claim 28 PM) were obtained, characterized in terms of chemistry and morphology, and fractioned to the respirable (≤ 10 microm) fraction. Mice were dosed with either PM sample, uranyl acetate, or vanadyl sulfate via aspiration (100 microg), with assessments of pulmonary and vascular toxicity 24 h later. Particulate matter samples were also examined for in vitro effects on cytotoxicity, oxidative stress, phagocytosis, and inflammasome induction. Claim 28 PM10 was highly enriched with U and V and exhibited a unique nanoparticle ultrastructure compared with background PM10. Claim 28 PM10 exhibited enhanced pulmonary and vascular toxicity relative to background PM10. Both U and V exhibited complementary pulmonary inflammatory potential, with U driving a classical inflammatory cytokine profile (elevated interleukin [IL]-1b, tumor necrosis factor-alpha, and keratinocyte chemoattractant/human growth-regulated oncogene) while V preferentially induced a different cytokine pattern (elevated IL-5, IL-6, and IL-10). Claim 28 PM10 was more potent than background PM10 in terms of in vitro cytotoxicity, impairment of phagocytosis, and oxidative stress responses. Resuspended PM10 derived from U mine waste exhibit greater cardiopulmonary toxicity than background dusts. Rigorous exposure assessment is needed to gauge the regional health risks imparted by these unremediated sites. [Description provided by NIOSH]
• Subjects:
  Dust Environmental Pollution Immune System Metals Occupational Health Particulate Matter Safety Toxicology Vanadium
• Keywords:
  Abandoned Mines Author Keywords: Uranium Cardiopulmonary Cardiopulmonary System Disorders Cytokines Environmental Contamination Immune Reaction Immunotoxicology Inflammation Metal Dusts Nanoparticles Oxidative Stress Particulates Phagocytic Activity Respirable Dust Respiratory Toxicology Uranium

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  101-114
• Volume:
  164
• Issue:
  1
• NIOSHTIC Number:
  nn:20051493
• Citation:
  Toxicol Sci 2018 Jul; 164(1):101-114
• Contact Point Address:
  Matthew J. Campen, Department of Pharmaceutical Sciences, College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131-5691
• Email:
  mcampen@salud.unm.edu
• CAS Registry Number:
  Uranium (CAS RN 7440-61-1) ; Vanadium (CAS RN 7440-62-2)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Toxicological Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f28e480418fbdf35c06349fdaf7632f71f8654787f5e68a9c27baac949f80a065a80d91e2834c95a6946b3d1ee6539d8eaec1e8a54e465bdba246f46d9d5bce3
• Download URL:
  https://stacks.cdc.gov/view/cdc/211415/cdc_211415_DS1.pdf
• File Type:
  [PDF - 1.46 MB ]