Melanoma, Thyroid Cancer, and Gynecologic Cancers in a Cohort of Female Flight Attendants

Details

• Personal Author:
  Anderson, Jeri L. ; Christianson A ; Hein, Misty J. ; Little D ; Phil MP ; Pinkerton LE ; Schubauer-Berigan, Mary K. ; Sigurdson AJ
• Description:
  Background: Flight attendants may have an increased risk of some cancers from occupational exposure to cosmic radiation and circadian disruption. Methods: The incidence of thyroid, ovarian, and uterine cancer among approximately 6000 female flight attendants compared to the US population was evaluated via life table analyses. Associations of these cancers, melanoma, and cervical cancer with cumulative cosmic radiation dose and metrics of circadian disruption were evaluated using Cox regression. Results: Incidence of thyroid, ovarian, and uterine cancer was not elevated. No significant, positive exposure-response relations were observed. Weak, non-significant, positive relations were observed for thyroid cancer with cosmic radiation and time zones crossed and for melanoma with another metric of circadian disruption. Conclusions: We found little evidence of increased risk of these cancers from occupational cosmic radiation or circadian disruption in female flight attendants. Limitations include few observed cases of some cancers, limited data on risk factors, and misclassification of exposures. [Description provided by NIOSH]
• Subjects:
  Aircraft Circadian Rhythm Cohort Studies Neoplasms Occupational Exposure Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Aircrews Author Keywords: Cancer Circadian Rhythm Disruption Circadian Rhythms Cohort Studies Cosmic Ionizing Radiation Cosmic Radiation Exposure Response Flight Attendants Flight Personnel Occupational Exposure Ovarian Cancer Thyroid Gland Disorders Uterine Cancer

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  61
• Issue:
  7
• NIOSHTIC Number:
  nn:20051380
• Citation:
  Am J Ind Med 2018 Jul; 61(7):572-581
• Contact Point Address:
  Lynne E. Pinkerton, MD, MPH, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 1090 Tusculum Ave., R-15, Cincinnati, OH 45226
• Email:
  lep5@cdc.gov
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:894f0279deb3ff75487f81d77dfc9902d2707472eb518323f5feb7c27e7c3a1b61025bd43d7babc3a8bc6ec4b46c84de282e52c297e2939a69affe7fa235db82
• Download URL:
  https://stacks.cdc.gov/view/cdc/211369/cdc_211369_DS1.pdf
• File Type:
  [PDF - 412.83 KB ]