Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, Insulin Resistance, and Endothelial Dysfunction in Children

Details

• Personal Author:
  Attina T ; Brody R ; Kannan K ; Kataria A ; Levine D ; Morrison D ; Rajendiran K ; Thurman JM ; Trachtman H ; Trasande L ; Urbina E ; Vento S ; Wertenteil S ; Xue J
• Description:
  Background: The health effects of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) have been studied extensively in children. The impact of other chemicals in these two classes has not been investigated as fully. Methods: We conducted a cross-sectional pilot study of 10-13 y old healthy children. We assessed descriptive, univariable, and multivariable associations of urinary metabolites of bisphenols and phthalates with oxidant stress, insulin resistance, body mass, and endothelial dysfunction. Possible associations with brachial artery distensibility, pulse wave velocity (markers of vascular stiffness), and serum endothelial cellderived microparticle levels were also assessed. Results: We enrolled 41 participants, 12.1 +/- 1.0 y, most of whom were Mexican Americans (42%) or other Hispanics (34%). Increased BPA levels were associated with increased levels of F2-isoprostane (ng/ml) (P = 0.02), with a similar trend for DEHP metabolites. Each log unit increase of high molecular weight (HMW) phthalate metabolites was associated with a 0.550 increase in Homeostatic Model Assessment of insulin resistance (HOMA-IR) units (P = 0.019) and altered circulating levels of activated endothelial cell-derived microparticles (% per ml) (P = 0.026). Bisphenol S (BPS), a replacement for BPA, was associated with increased albumin (mg):creatinine (g) ratio (P = 0.04). Metabolites of HMW phthalates were also associated with decreased brachial artery distensibility (P = 0.047). Conclusion: Exposure to bisphenols and phthalates, including a BPA replacement, is associated with increased oxidant stress, insulin resistance, albuminuria, as well as disturbances in vascular function in healthy children. [Description provided by NIOSH]
• Subjects:
  Diet Energy Metabolism Environmental Exposure Occupational Health Race Factors Risk Assessment Risk Factors Safety Urine
• Keywords:
  Bisphenol A BMI Body Mass Index Chemicals Children Endothelial Cells Exposure Levels Food Health Effects Humans Metabolites Obesity Oxidative Stress Racial Factors Risk Factors Sociological Factors Urinalysis

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• ISSN:
  0031-3998
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; New York ; Ohio ; OSHA Region 2 ; OSHA Region 5 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  81
• Issue:
  6
• NIOSHTIC Number:
  nn:20051285
• Citation:
  Pediatr Res 2017 Jun; 81(6):857-864
• Email:
  howard.trachtman@nyumc.org
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7) ; Dioctyl phthalate (CAS RN 117-81-7)
• Federal Fiscal Year:
  2017
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20150701
• Source Full Name:
  Pediatric Research
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4f74aa0562c79f2e53d5dbc5ab1829f3307546ab391ad08ba27a56fad88bb4967dc0687f954d906e540fee1c5780880fcde2c8e8adc576929a5549c7b5479200
• Download URL:
  https://stacks.cdc.gov/view/cdc/211331/cdc_211331_DS1.pdf
• File Type:
  [PDF - 1.13 MB ]