Influence of Genetic Variance on Occupational Exposure to 1,6-Hexamethylene Diisocyanate Isocyanurate

Details

• Personal Author:
  Taylor L
• Description:
  Exposure to diisocyanates is a leading cause of occupational asthma around the world. We investigated the potential of genetic polymorphic markers to affect urine biomarker trisaminohexyl isocyanurate (TAHI) levels in 33 automotive spray-painters exposed to 1,6-hexamethylene diisocyanate (HDI) isocyanurate, an oligomer of HDI. Genome-wide association analysis using a false discovery rate of q<0.20 indicated that one single nucleotide polymorphic (SNP) marker, rs12955846, was significantly associated with urine TAHI levels after controlling for four covariates (current smoking status, ethnicity, and inhalation and skin exposure to HDI isocyanurate). Linear mixed effects model showed that this SNP explained 70% of the biomarker variance. In bioinformatics evaluation, we identified and evaluated coding genes and potential regulatory elements that are proximal to the ten most influential SNPs. The methodology presented here has the potential to inform us on individual susceptibility factors that may affect biomarker levels of HDI isocyanurate exposure. [Description provided by NIOSH]
• Subjects:
  Asthma Automobiles Biomarkers Environmental Exposure Genetics Isocyanates Occupational Health Paint Race Factors Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Skin Smokers Toxicology Urine

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• Keywords:
  Author Keywords: Toxicology Automotive Industry Bioinformatics Bronchial Asthma Diisocyanates Exposure Assessment Exposure Levels Genome-wide Analysis Genomics Hexamethylene Diisocyanate Models Occupational Safety Paints Racial Factors Risk Factors Skin Exposure Smoking Spray Painting

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• Publisher:
  University of North Carolina
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Thesis
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-44
• NIOSHTIC Number:
  nn:20051013
• Citation:
  Chapel Hill, NC: University of North Carolina, 2017 May; :1-44
• CAS Registry Number:
  Hexamethylene diisocyanate (CAS RN 822-06-0)
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of North Carolina Chapel Hill
• Peer Reviewed:
  False
• Start Date:
  20140901
• Source Full Name:
  Influence of genetic variance on occupational exposure to 1,6-hexamethylene diisocyanate isocyanurate
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ad6bbbc02bf3a2e0ac3997be21cdaaa80d59b8e5074ad8396674d797e7bc71bb116d6395ef006c386d24959c6ad61e3811bde3739ea036fe8ecc81c5e6c932f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/211155/cdc_211155_DS1.pdf
• File Type:
  [PDF - 1.26 MB ]