Use of Pathogen-Specific Antibody Biomarkers to Estimate Waterborne Infections in Population-Based Settings

Details

• Personal Author:
  Detrick B ; Egorov A ; Exum NG ; Granger DA ; Griffin SM ; Heaney CD ; Kosek M ; Pisanic N ; Schwab KJ
• Description:
  PURPOSE OF REVIEW: This review discusses the utility of pathogen-specific antibody biomarkers for improving estimates of the population burden of waterborne infections, assessing the fraction of infections that can be prevented by specific water treatments, and understanding transmission routes and the natural history and ecology of disease in different populations (including asymptomatic infection rates). RECENT FINDINGS: We review recent literature on the application of pathogen-specific antibody response data to estimate incidence and prevalence of acute infections and their utility to assess the contributions of waterborne transmission pathways. Advantages and technical challenges associated with the use of serum versus minimally invasive salivary antibody biomarkers in cross-sectional and prospective surveys are discussed. We highlight recent advances and challenges and outline future directions for research, development, and application of antibody-based and other immunological biomarkers of waterborne infections. [Description provided by NIOSH]
• Subjects:
  Antibodies Biomarkers Occupational Health Safety
• Keywords:
  Author Keywords: Antibodies Diseases Disease Transmission Immunoconversion Infectious Agents Pathogens Saliva Serology Waterborne Infections Water Supply
• ISSN:
  2196-5412
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Maryland ; North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  322-334
• Volume:
  3
• Issue:
  3
• NIOSHTIC Number:
  nn:20050945
• Citation:
  Curr Environ Health Rep 2016 Sep; 3(3):322-334
• Contact Point Address:
  ChristopherD.Heaney, Department of Epidemiology, Johns Hopkins Bloomberg School of PublicHealth, Johns Hopkins University, Room W7033B, 615 North Wolfe Street, Baltimore, Maryland 21205-2179
• Email:
  cheaney1@jhu.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  Johns Hopkins University, Baltimore, Maryland
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  Current Environmental Health Reports
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ffed5035f94c9d1315b4c551f6e834cf011660e5ad78a6726c57c5c4714653d56eab2c339f87b5ca95041980b6f11fe871ac82566fb4039e02527b88a3a4f4e9
• Download URL:
  https://stacks.cdc.gov/view/cdc/211122/cdc_211122_DS1.pdf
• File Type:
  [PDF - 606.46 KB ]