Inhalable Particle Exposures in Northern Colorado Dairies

Details

• Personal Author:
  Anderson, Kern E. ; Anthony, T. Renée ; Bradford M ; Mehaffy J ; Reynolds S ; Scaeffer J ; Sleeth D ; Tryon J ; VanDyke A ; Volckens J ; Anderson, Kern E. ; Anthony, T. Renée ; Bradford M ; Mehaffy J ; Reynolds S ; Scaeffer J ; Sleeth D ; Tryon J ; VanDyke A ; Volckens J
• Description:
  Exposure to bioaerosols is associated with a multitude of adverse health effects (asthma, chronic bronchitis, wheeze and cough. The Personal Inhalable High-Flow Sampling Head (PHISH) sampler is a new low-cost, disposable inhalable sampler that operates at 10 L/min. This study evaluated worker exposures to dust and endotoxin in dairy parlors using PHISH, 37-mm CFC, and Button samplers. Inflammation of the upper respiratory system was evaluated by evaluating cytokine levels in nasal lavage. Personal air monitoring was conducted over three work shifts and on the workers' day off to quantify inhalable dust and endotoxin. Samples were analyzed gravimetrically and compared between the PHISH, CFC, and Button. Post-shift nasal lavage fluids were assessed for interleukin 1-beta, 6, 8 and 10 (IL-1 beta, IL-6, IL-8, and IL- 10), TNF-alpha, and IFN-gamma. Total endotoxin concentrations for the PHISH sampler were 12 times higher than those measured in the CFC sampler. Differences in cytokine levels were identified by gender and smoking status. In general, women had lower baseline cytokine levels compared to men, and a more substantial increase in cytokine levels after one day of exposure. Current smokers had higher baseline levels of TNF-alpha, IL1-beta, and IL-10. Levels of IL1, IL-6, and IL-8 decreased with increasing number of days worked. Levels of TNF-alpha and IFN-gamma increased slightly with increased number of days worked. No significant differences were seen in cytokine expression or in pulmonary function between new workers (<1 year) compared to participants who have worked for longer than one year. Preliminary data analysis suggests that baseline cytokine level, gender, smoking status, season, and dairy have an effect on cytokine levels. The PHISH mass concentration and total endotoxin units had slightly stronger correlations between most cytokine levels compared to the CFC mass concentration and endotoxin levels. [Description provided by NIOSH]
• Subjects:
  Agriculture Asthma Dairy Products Dust Endotoxins Environmental Exposure Farmers Lung Diseases Men Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Women Workplace

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• Keywords:
  Agricultural Agricultural Workers Bioaerosols Bronchial Asthma Bronchitis Dairy Products Dust Exposure Dusts Exposure Levels Farm Workers Health Effects Humans Monitoring Systems Pulmonary System Disorders Respiratory System Disorders Risk Assessment Risk Factors Samplers Work Environment Workers

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• Publisher:
  American Association for Aerosol Research
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary ; Abstract or Summary
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• NIOSHTIC Number:
  nn:20050928
• Citation:
  Proceedings of the AAAR 34th Annual Conference, October 12-16, 2015, Minneapolis, Minnesota. Mount Laurel, NJ: American Association for Aerosol Research, 2015 Oct; :7AG.4
• Federal Fiscal Year:
  2016
• Performing Organization:
  Colorado State University
• Peer Reviewed:
  False
• Start Date:
  20120701
• Source Full Name:
  Proceedings of the AAAR 34th Annual Conference, October 12-16, 2015, Minneapolis, Minnesota
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:24deed96f29b2bdda7bc1e2569d7c84e74b2e1a75169c589db54c3dff4155570504cfec2371c146422c361059ecc7d9b8f4fdb3e36196546492d192bd504b7ce
• Download URL:
  https://stacks.cdc.gov/view/cdc/211108/cdc_211108_DS1.pdf
• File Type:
  [PDF - 67.93 KB ]