Details:

Alternative Title:
Am J Trop Med Hyg
Publisher's site:
http://dx.doi.org/10.4269/ajtmh.13-0140
Personal Author:
Duggal, Nisha K. ; D'Anton, Mary ; Xiang, Jeannie ; Seiferth, Robyn ; Day, Joanne ; ... More +
Duggal, Nisha K. ; D'Anton, Mary ; Xiang, Jeannie ; Seiferth, Robyn ; Day, Joanne ; Nasci, Roger ; Brault, Aaron C. Less -
Description:
In 2012, Texas experienced the largest outbreak of human West Nile encephalitis (WNE) since the introduction of West Nile virus (WNV) in 2002. Despite the large number of WNV infections, data indicated the rate of reported WNE among human cases was no higher than in previous years. To determine whether the increase in WNV human cases could have been caused by viral genetic changes, the complete genomes of 17 isolates made from mosquito pools in Dallas and Montgomery Counties in 2012 were sequenced. The 2012 Texas isolates were found to be composed of two distinct clades, both circulating in Dallas and Montgomery Counties despite a 5-fold higher disease incidence in the former. Although minor genetic differences existed between Dallas and Montgomery WNV populations, there was weak support for population subdivision or adaptive changes. On the basis of these data, alternative explanations for increased WNV disease incidence in 2012 are proposed.
Subjects:
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Base Sequence Disease Outbreaks Genetic Variation Genotype Humans Incidence Likelihood Functions Mutation Phylogeny RNA, Viral Sequence Alignment Sequence Analysis West Nile Fever West Nile Virus
Source:
Am J Trop Med Hyg. 2013; 89(2):205-210.
Document Type:
Journal Article
Place as Subject:
Texas
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4a581d78fa3503c7d454ce56fe6a955e4d6abba8c061fa5975f9e1268c521487
Download URL:
https://stacks.cdc.gov/view/cdc/21109/cdc_21109_DS1.pdf
File Type:

Supporting Files

• 	license.txt	txt
  	SD1.pdf	pdf
  	tropmed-89-205-g001.gif	gif
  	tropmed-89-205-g001.jpg	jpeg
  	tropmed-89-205-g002.gif	gif
  	tropmed-89-205-g002.jpg	jpeg
  	tropmed-89-205.nxml	txt

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