YKL-40 Is a Protective Biomarker for Fatty Liver in World Trade Center Particulate Matter-Exposed Firefighters

Details

• Personal Author:
  Cho SJ ; Echevarria GC ; Kwon S ; Lee YI ; Nolan A ; Park KY ; Prezant DJ ; Rom, William N. ; Tsukiji J ; Weiden MD
• Description:
  Background: Serum biomarkers of metabolic syndrome predict abnormal lung function in World Trade Center particulate matter (WTC-PM)-exposed Fire Department of New York (FDNY) rescue workers. In animal models, exposure to ambient PM induces non-alcoholic fatty liver disease (NAFLD), a well-known comorbidity of metabolic syndrome. YKL-40 is an inflammatory biomarker for both liver and lung disease. We tested if YKL-40 is a biomarker for NAFLD in this dust-exposed cohort. Methods: Using a nested case-control design, we studied 131 FDNY personnel who had Computer Tomography performed within 5 years post 9/11. NAFLD was defined by a liver/spleen attenuation ratio of <1. Serum biomarkers, lipid panel and liver function were measured in serum that had been drawn within 6 months of September 11, 2001. YKL-40 and chitotriosidase were assayed by ELISA. We tested biomarker and NAFLD association using logistic regression adjusted for age, BMI, and post-911 lung function. Results: NAFLD was present in 29/131 (22%) of the cohort. In a multivariable model increasing YKL-40 was protective while increasing triglyceride and alkaline phosphatase were risk factors for NAFLD. Conclusions: Increased YKL-40 is a protective biomarker in non-alcoholic fatty liver disease. Further studies may reveal a link between PM-induced lung and liver diseases. [Description provided by NIOSH]
• Subjects:
  Aging Animals Biomarkers Environmental Exposure Firefighters Laboratories Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

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• Keywords:
  Age Groups Author Keywords: YKL-40 Biomarker BMI Body Mass Index Exposure Levels Fire Fighters Laboratory Animals Liver Liver Disease Lung Disease Lung Function Metabolic Disorders Models Non-alcoholic Fatty Liver Disease Particulates Risk Factors World Trade Center WTC

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• ISSN:
  2155-9929
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• Issue:
  3
• NIOSHTIC Number:
  nn:20050874
• Citation:
  J Mol Biomark Diagn 2014 Mar; 5(3):1000174
• Contact Point Address:
  Michael D. Weiden, Associate Professor of Medicine and Environmental Medicine, New York University School of Medicine, 550 1st Ave, New York, NY 10016
• Email:
  michael.weiden@med.nyu.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20110701
• Source Full Name:
  Journal of Molecular Biomarkers & Diagnosis
• End Date:
  20170331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a6ae48520b215774432d7e3a45ecd749a89353cbb7752c0fe2f54590456cc7991f65b6ba5839d8237486a47bce0907c5f36a1ac7626557dc466938198c770a62
• Download URL:
  https://stacks.cdc.gov/view/cdc/211067/cdc_211067_DS1.pdf
• File Type:
  [PDF - 867.26 KB ]