Biomarkers of patient intrinsic risk for upper and lower airway injury after exposure to the World Trade Center atrocity

Details

• Personal Author:
  Nolan A ; Prezant DJ ; Putman B ; Singh A ; Weiden MD ; Zeig-Owens R
• Description:
  Background: High rates of upper and lower airways disease have occurred in Fire Department of the City of New York (FDNY) workers exposed to the World Trade Center (WTC) disaster site. Most experienced acute declines in pulmonary function, and some continued to experience decline over 14 years of follow-up. Similarly, some with rhinosinusitis had symptoms requiring sinus surgery. Aim: To increase generalizability of biomarker investigation, we describe biomarkers of risk for upper and lower airway injury that do not require stored serum. Methods: We review WTC biomarker literature. Results: Cytokines expressed in stored serum from the first 6 months post-9/11 can identify individuals at higher risk for future abnormal pulmonary function. Conclusion: This research will help identify individuals at high risk of lung and sinus disease that develop after these, or future, irritant exposures for intensive monitoring and treatment. Itmay also identify targets for effective therapeutic interventions. [Description provided by NIOSH]
• Subjects:
  Biomarkers Dust Environmental Exposure Firefighters Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Workplace

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• Keywords:
  Airways Disease Author Keywords: World Trade Center Cytokines Diseases Dust Exposure Dusts Exposure Levels Fire Fighters Lung Function Lung Injury Predictive Biomarkers Pulmonary Function Pulmonary System Pulmonary System Disorders Respiratory Function Respiratory System Disorders Risk Factors Work Environment Workers World Trade Center WTC

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Contract ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  9
• NIOSHTIC Number:
  nn:20048590
• Citation:
  Am J Ind Med 2016 Sep; 59(9):788-794
• Contact Point Address:
  Rachel Zeig-Owens, DrPH, MPH, The Bureau of Health Services, Fire Department of New York City, 9 Metrotech Center, 5E-63-K, Brooklyn, NY 11201
• Email:
  Rachel.Zeig-Owens@fdny.nyc.gov
• Federal Fiscal Year:
  2016
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20140701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:27fd0ab0e9e89c999ea484ec7c9d77e1c9320cae41557982beeec54dede3bd5798037edfb0bc1b940d3d14c63e5707aa523978311aa2c2093918d44cf84ef645
• Download URL:
  https://stacks.cdc.gov/view/cdc/203311/cdc_203311_DS1.pdf
• File Type:
  [PDF - 152.54 KB ]