Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry

Details

• Personal Author:
  Anteau S ; Carson M ; Cassidy LD ; Collins JJ ; Conner PR ; Doney B ; Kurth L ; Molenaar D ; Redlich CA ; Storey, Eileen ; Wang, Mei Lin
• Description:
  Objective: This study examines asthma risk in facilities producing toluene diisocyanate (TDI). Methods: A total of 197 workers were monitored from 2007 to 2012. TDI air concentrations were used to estimate exposures. Results: The incidence of cases consistent with TDI-induced asthma was 0.009 per person-years (seven cases) or consistent with TDI-induced asthma or asthma indeterminate regarding work-relatedness was 0.012 (nine cases). Increased risk of cases consistent with TDI asthma was observed for cumulative (odds ratio [OR=2.08, 95% confidence interval [CI] 1.07 to 4.05) per logarithm parts per billion-years and peak TDI exposures (OR=1.18, 95% CI 1.06 to 1.32) (logarithm parts per billion). There was a weak association with cumulative and peak exposures for decline of short-term forced expiratory volume in one second (FEV1). Asthma symptoms were associated with workers noticing an odor of TDI (OR 6.02; 95% CI 1.36 to 26.68). Conclusions: There is evidence that cumulative and peak exposures are associated with TDI-induced asthma. [Description provided by NIOSH]
• Subjects:
  Asthma, Occupational Epidemiology Isocyanates Manufacturing And Industrial Facilities Occupational Health Safety
• Keywords:
  Chemical Manufacturing Industry Diisocyanates Occupational Asthma Toluene-2,4-diisocyanate Toluene-2,6-diisocyanate
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Michigan ; New Jersey ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; West Virginia ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• NIOSHTIC Number:
  nn:20050800
• Citation:
  J Occup Environ Med 2017 Dec; 59(Suppl 12):S22-S27
• Contact Point Address:
  James J. Collins, PhD, Department of Health Sciences, Saginaw Valley State University, 7400 Bay Road, University Center, Saginaw, MI 48710
• Email:
  jjcollin@svsu.edu
• CAS Registry Number:
  Toluene diisocyanate (CAS RN 26471-62-5)
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Supplement:
  12
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d904c287d0cd6eabb5be52cc6d951d1b83d666e887f1c79170aae424c0ce25bf20dff213aeee2df7a7d300063f3a63ed543c0e9a499a936103f44e8680c3f755
• Download URL:
  https://stacks.cdc.gov/view/cdc/211012/cdc_211012_DS1.pdf
• File Type:
  [PDF - 118.42 KB ]