Toluene Diisocyanate Exposure: Exposure Assessment and Development of Cross-Facility Similar Exposure Groups Among Toluene Diisocyanate Production Plants

Details

• Personal Author:
  Doney B ; Feeley T ; Middendorf, Paul J. ; Miller, William E.
• Description:
  Objective: The objective of this study was to characterize workplace toluene diisocyanate (TDI) exposures using standardized industrial hygiene exposure assessment procedures for use in a prospective epidemiologic study of occupational asthma. Methods: Over 2300 representative routine full shift time-weighted average (TWA) and short-term high potential exposure tasks (HPETs) air samples in groups across three TDI plants were collected over a nearly 7-year period. Results: Data-derived similar exposure groups (SuperSEGs) were developed across the plants based on TWA sampling using cluster analysis. Individual cumulative exposure estimates were developed on the basis of the SuperSEGs. Conclusion: Workplace TWA exposures to TDI were adequately characterized quantitatively, but HPET exposures were adequately characterized only by qualitative measures. The mean TWA exposure was 0.65 parts per billion for 1594 routine samples. These TWA and HPETexposures can be used to support exposure-response analyses. [Description provided by NIOSH]
• Subjects:
  Asthma, Occupational Epidemiology Isocyanates Manufacturing And Industrial Facilities Occupational Health Safety
• Keywords:
  Chemical Manufacturing Industry Diisocyanates Exposure Assessment Occupational Asthma Toluene-2,4-diisocyanate Toluene-2,6-diisocyanate
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 3 ; OSHA Region 4 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OD - Office of the Director ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• NIOSHTIC Number:
  nn:20050799
• Citation:
  J Occup Environ Med 2017 Dec; 59(Suppl 12):S1-S12
• Contact Point Address:
  Paul J. Middendorf, PhD, Deputy Associate Director for Science, Office of the Director (NIOSH), 2400 Century Parkway NE, Atlanta, GA 30345
• Email:
  pmiddendorf@cdc.gov
• CAS Registry Number:
  Toluene diisocyanate (CAS RN 26471-62-5)
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Supplement:
  12
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dce6d017a2a2bc164df1d247d128f771ab9350833fbbbd8792fdb5e333bb30c38bfad44f59a2989d7118e97de8c5acc913e17f22de767da3a6aa44c7813bbc1a
• Download URL:
  https://stacks.cdc.gov/view/cdc/211011/cdc_211011_DS1.pdf
• File Type:
  [PDF - 359.19 KB ]