Polymorphism in the Hypoxia-Inducible Factor 1alpha Gene May Confer Susceptibility to LDD in Chinese Cohort

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Lin, Wen-Ping ; Wang, Xue-Jin ; Wang, Cong-Ren ; Zhang, Li-Qun ; Li, Neng ; Wang, Fa-Sheng ; Lin, Jian-Hua
• Description:
  Objective
  
  This study aimed to investigate whether or not hypoxia-inducible factor-1α (HIF-1α) gene variants are associated with the susceptibility and clinical characteristics of lumbar disc degeneration (LDD).
  
  Methods
  
  We examined 320 patients with LDD and 447 gender- and age-matched control subjects. We also determined the HIF-1α gene variants, including C1772T (P582S) and G1790A (A588T) polymorphisms.
  
  Results
  
  Significant differences were observed in allelic and genotypic distributions of 1790 A > G polymorphisms between LDD cases and control subjects. Logistic regression revealed that 1790 AA genotypes indicated a protective effect against the development of LDD. The HIF-1α 1790 A > G polymorphisms also affected the severity of LDD as evaluated based on the modified Japanese Orthopedic Association (mJOA) scores. The 1790 AA genotype carriers exhibited significantly lower mJOA scores than AG and GG carriers. C1772T did not show any association with the risk and severity of LDD.
  
  Conclusion
  
  Our study suggested that HIF-1α 1790 A > G polymorphisms may be used as a molecular marker to determine the susceptibility and severity of LDD.
  
  
• Subjects:
  Adult Alleles Case-Control Studies Cohort Studies Female Genetic Predisposition To Disease Humans Hypoxia-Inducible Factor 1, Alpha Subunit Intervertebral Disc Degeneration Intervertebral Disc Displacement Male Middle Aged Polymorphism, Genetic

  More +
• Source:
  PLoS One. 2013; 8(8).
• Document Type:
  Journal Article
• Place as Subject:
  China
• Volume:
  8
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fe87b95640a0a82454dc808e4682ca32720e5cbd7f5c581869e7e98e7e5f2b96
• Download URL:
  https://stacks.cdc.gov/view/cdc/21100/cdc_21100_DS1.pdf
• File Type:
  [PDF - 623.79 KB ]