Evaluation of 1-Nitropyrene as a Surrogate Measure for Diesel Exhaust

Details

• Personal Author:
  Carpenter EE ; Paulsen MH ; Pyke C ; Ramsay J ; Riley EA ; Seixas, Noah S. ; Sheppard L ; Simpson CD ; Spear TM ; Stephenson DJ ; Zamzow E
• Description:
  We investigated the viability of particle bound 1-nitropyrene (1-NP) air concentration measurements as a surrogate of diesel exhaust (DE) exposure, as compared with industry-standard elemental carbon (EC) and total carbon (TC) measurements. Personal exposures are reported for 18 employees at a large underground metal mine during four different monitoring campaigns. Full-shift personal air exposure sampling was conducted using a Mine Safety and Health Administration (MSHA) compliant diesel particulate matter (DPM) impactor cassette downstream of a GS-1 cyclone pre-selector. Each DPM filter element was analyzed for EC and organic carbon (OC) using NIOSH Method 5040. After EC and OC analysis, the remaining portion of each DPM filter was analyzed for 1-NP using liquid chromatography tandem mass spectrometry (LC/MS/MS). We observed high correlations between the quantiles of 1-NP and EC exposures across 10 different work shift task groups (r = 0.87 to 0.96), and a linear relationship with a slope between 6.0 to 6.9 pg 1-NP per ug EC. However, correlation between 1-NP and EC was weak (r =0.34) for the 91 individual sample pairs due to low EC concentrations and possible heterogeneity of DE composition. While both 1-NP and EC differentiated between high and low exposure groups categorized by job location, measurements of 1-NP, but not EC further differentiated between specific job activities. Repeated measurements on individual subjects verified the relationship between 1-NP and EC and demonstrated substantial within-subject variability in exposure. The detection limit of TC air concentration ranged between 18 and 28 ug m-3 and was limited by OC contamination of the quartz filters in the MSHA compliant DPM samplers. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Mining Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Vehicle Emissions
• Keywords:
  1-Nitropyrene Author Keywords: Elemental Carbon Carbon Diesel Exhausts Exposure Assessment Exposure Levels Filters Metal Mining Mine Safety And Health Administration Monitoring Systems MSHA Organic Carbon Particulate Matter Particulates Risk Factors Sampling Total Carbon Underground Mining

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• ISSN:
  2398-7308
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Idaho ; Montana ; OSHA Region 10 ; OSHA Region 8 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  339-350
• Volume:
  62
• Issue:
  3
• NIOSHTIC Number:
  nn:20050759
• Citation:
  Ann Work Expo Health 2018 Apr; 62(3):339-350
• Contact Point Address:
  Christopher D. Simpson, 1Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA 98125
• Email:
  simpson1@uw.edu
• CAS Registry Number:
  1-Nitropyrene (CAS RN 5522-43-0) ; Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20130901
• Source Full Name:
  Annals of Work Exposures and Health
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e7e3b58d4ea03f0a616d1d9bce7c393a7a3f90f5559bb470075ca32d58ba51048fdbb2f44efe763ad428e88ee65a159c4ac8957212cfe56aeb0041663b4ec279
• Download URL:
  https://stacks.cdc.gov/view/cdc/210982/cdc_210982_DS1.pdf
• File Type:
  [PDF - 457.57 KB ]