Characterization of Engineered Nanoparticles in Commercially Available Spray Disinfectant Products Advertised to Contain Colloidal Silver

Details

• Personal Author:
  Al-Abed SR ; Bowers L ; Bradham KD ; Gitipour A ; Knepp AK ; Navratilova J ; Nelson C ; Potter P ; Radwan I ; Rogers KR ; Stefaniak, Aleksandr B.
• Description:
  Given the potential for human exposure to silver nanoparticles from spray disinfectants and dietary supplements, we characterized the silver-containing nanoparticles in 22 commercial products that advertised the use of silver or colloidal silver as the active ingredient. Characterization parameters included: total silver, fractionated silver (particulate and dissolved), primary particle size distribution, hydrodynamic diameter, particle number, and plasmon resonance absorbance. A high degree of variability between claimed and measured values for total silver was observed. Only 7 of the products showed total silver concentrations within 20% of their nominally reported values. In addition, significant variations in the relative percentages of particulate vs. soluble silver were also measured in many of these products reporting to be colloidal. Primary silver particle size distributions by transmission electron microscopy (TEM) showed two populations of particles - smaller particles (< 5 nm) and larger particles between 20 and 40 nm. Hydrodynamic diameter measurements using nanoparticle tracking analysis (NTA) correlated well with TEM analysis for the larger particles. Z-average (Z-Avg) values measured using dynamic light scattering (DLS); however, were typically larger than both NTA or TEM particle diameters. Plasmon resonance absorbance signatures (peak absorbance at around 400 nm indicative of metallic silver nanoparticles) were only noted in 4 of the 9 yellow-brown colored suspensions. Although the total silver concentrations were variable among products, ranging from 0.54 mg/L to 960 mg/L, silver containing nanoparticles were identified in all of the product suspensions by TEM. [Description provided by NIOSH]
• Subjects:
  Disinfectants Metals Occupational Health Particulate Matter Safety Silver
• Keywords:
  Author Keywords: Colloidal Colloids Dietary Supplement Electron Microscopy Exposure Assessment Fluids Food Additives Human Exposure Hydrodynamics Light Emission Metallurgy Nanoparticle Nanoparticles Nanotechnology Particle Diameter Particle Size Particle Size Analysis Silver Compounds Spray Disinfectant Sprays Vitamins

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• ISSN:
  0048-9697
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  619
• NIOSHTIC Number:
  nn:20050711
• Citation:
  Sci Total Environ 2018 Apr; 619-620:1375-1384
• Contact Point Address:
  Kim R. Rogers, U.S. Environmental Protection Agency, RTP, NC, United States
• Email:
  rogers.kim@epa.gov
• CAS Registry Number:
  Silver (CAS RN 7440-22-4)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Healthcare and Social Assistance
• Peer Reviewed:
  True
• Source Full Name:
  Science of the Total Environment
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:08faed4bff366f0d00d61bc6f2d26e087d83297926fe15b8bac2777e5a5470d2e827173e362d486d187e4dfb6a141f28ea3301ac9facf13713641c840a91034e
• Download URL:
  https://stacks.cdc.gov/view/cdc/210952/cdc_210952_DS1.pdf
• File Type:
  [PDF - 1.71 MB ]