Effect of Manganese and Manganese plus Noise on Auditory Function and Cochlear Structures

Details

• Personal Author:
  Chen G-D ; Ding D ; Muthaiah VPK ; Roth JA ; Salvi R
• Description:
  The degenerative actions of Mn caused by persistent exposure to high atmospheric levels not only provokes irreversible damage to the CNS with symptoms comparable to that of Parkinson's disease but also may have deleterious consequences to other organs including the auditory system. The putative deleterious consequences of prolonged Mn overexposure on hearing, however, is confounded by the fact that chronically-exposed individuals often work in high noise environments where noise by itself is known to cause hearing loss. Thus, the question as to whether Mn alone is actually ototoxic and whether exposure to Mn when combined with noise increases the risk of hearing loss and cochlear pathology has never been examined. To examine whether noise effects Mn ototoxicity, we exposed rats to a moderate dose of Mn (10 mg MnCl2/liter water) alone, a high level of noise (octave band noise, 8-16 kHz, presented at 90 dB SPL for 8 h/d) alone or the combination of Mn plus noise and measured the changes in auditory function and the cochlear histopathologies. Results of these studies, based on various measures of hearing including histological examination of cochlear tissue suggest that noise alone produced significant hearing deficits whereas semi-chronic exposure to moderate levels of Mn in drinking water for 90 days either in the presence or absence of noise had, at best, only a minor effect on hearing. [Description provided by NIOSH]
• Subjects:
  Ear Hearing Hearing Loss Hearing Loss, Noise-Induced Laboratories Manganese Minerals Nervous System Noise Noise, Occupational Occupational Exposure Occupational Health Pathology Safety Sense Organs

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• Keywords:
  Auditory-nerve Auditory-system Auditory System Author Keywords: Manganese Cell Damage Cellular-function Chronic Exposure Cochlea Ears Exposure-levels Hearing Acuity Hearing Impairment Hearing Loss Histopathology Laboratory Animals Manganese-compounds Nerve-fibers Nerve-function Nerves Noise Exposure Ototoxicity Rats

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• ISSN:
  0161-813X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  65-73
• Volume:
  55
• NIOSHTIC Number:
  nn:20050705
• Citation:
  Neurotoxicology 2016 Jul; 55:65-73
• Contact Point Address:
  Jerome A. Roth, Department of Pharmacology and Toxicology, 27 Cary Hall, University at Buffalo, Buffalo, NY 14214, USA
• Email:
  jaroth@buffalo.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2016
• Performing Organization:
  State University of New York - Buffalo
• Peer Reviewed:
  True
• Start Date:
  20120901
• Source Full Name:
  Neurotoxicology
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:46205819681139e28bd1d24cdb31ab6dc7e2086f18c42aeedd2c26068060827fbd6309709e6ca11201fba49e6721b46af62d6e72a35096cf5298a12fd5113dcd
• Download URL:
  https://stacks.cdc.gov/view/cdc/210946/cdc_210946_DS1.pdf
• File Type:
  [PDF - 1.77 MB ]