Sound-Induced Priming of the Chinchilla Auditory System

Details

• Personal Author:
  Ahroon WA ; Hamernik RP
• Description:
  Exposure of the auditory system to either continuous or interrupted nontraumatic noises, often collectively referred to as priming exposures, has been shown, in a number of experimental paradigms, to reduce the susceptibility of the auditory system to noise-induced hearing and sensory cell loss from a subsequent traumatic exposure. Using auditory evoked potentials to obtain pure-tone thresholds and cochleograms to quantify sensory cell losses, the issue of priming-induced protective effects was examined in the chinchilla. Priming was accomplished with either a continuous noise or with a continuous noise followed by an interrupted noise. Trauma was induced by exposure to high-level impacts over a 5-day period that resulted in an asymptotic threshold shift. A comparison of the two groups of primed subjects with an unprimed control group showed that there were some statistically significant reductions in the asymptotic response of the primed groups to the traumatic exposure but no differences in permanent changes in thresholds among the three groups 30 days following the traumatic exposure. There were, however, some statistically significant, frequency-specific, reductions in outer hair cell loss in the primed groups. When conditioning was followed by the interrupted exposure that produced a threshold shift toughening effect, the conditioning protocol had no effect on the response of subjects to the interrupted exposure. There were also no differences in thresholds or sensory cell loss between the two primed groups 30 days post-trauma. Priming protocols may have different effects on the development of noise-induced trauma that are dependent on the nature of the traumatic stimulus, that is, long-term high-level impact noise exposure versus acute continuous noise exposure. [Description provided by NIOSH]
• Subjects:
  Animals Ear Hearing Hearing Loss Hearing Loss, Noise-Induced Noise Noise, Occupational Occupational Health Safety Sense Organs
• Keywords:
  Animal-studies Auditory-nerve Auditory-system Author Keywords: Noise-induced Hearing Loss NIHL Cell-damage Conditioning Ear-disorders Hearing-disorders Hearing-impairment Hearing-loss Hearing-threshold Impulse-noise Industrial-noise Noise-exposure Noise-induced-hearing-loss Priming Protection Toughening

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• ISSN:
  0378-5955
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  127-136
• Volume:
  137
• Issue:
  1
• NIOSHTIC Number:
  nn:20029998
• Citation:
  Hear Res 1999 Nov; 137(1-2):127-136
• Contact Point Address:
  Auditory Research Laboratory, Plattsburgh State University of New York, 107 Beaumont Hall, Plattsburgh, NY 12901-2681
• Email:
  roger.hamernik@plattsburgh.edu
• Federal Fiscal Year:
  2000
• Performing Organization:
  Plattsburgh State University, New York
• Peer Reviewed:
  True
• Start Date:
  19860301
• Source Full Name:
  Hearing Research
• End Date:
  20130514
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:41bac405ac5528df5e2e0e0e712195fa14af3312592f6e4a3991d9492f6f32c4a7db4a49c2f9ff6c577c75ece9bb1e4720f3e630a2628a9dbc18af1ec95b2066
• Download URL:
  https://stacks.cdc.gov/view/cdc/190859/cdc_190859_DS1.pdf
• File Type:
  [PDF - 228.21 KB ]