Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder

Details

• Personal Author:
  Bennett DH ; Delwiche L ; Hansen RL ; Hertz-Picciotto I ; Kogan V ; Ma CC ; McCanlies EC ; Ozonoff S ; Schmidt RJ ; Shelton JF ; Tancredi DJ ; Volk HE ; Bennett DH ; Delwiche L ; Hansen RL ; Hertz-Picciotto I ; Kogan V ; Ma CC ; McCanlies EC ; Ozonoff S ; Schmidt RJ ; Shelton JF ; Tancredi DJ ; Volk HE
• Description:
  Background: Maternal folic acid (FA) protects against developmental toxicity from certain environmental chemicals. Objective: We examined combined exposures to maternal FA and pesticides in relation to autism spectrum disorder (ASD). Methods: Participants were California children born from 2000-2007 who were enrolled in the Childhood Autism Risks from Genetics and the Environment (CHARGE) case-control study at age 2-5 y, were clinically confirmed to have ASD (n=296) or typical development (n=220), and had information on maternal supplemental FA and pesticide exposures. Maternal supplemental FA and household pesticide product use were retrospectively collected in telephone interviews from 2003-2011. High vs. low daily FA intake was dichotomized at 800 µg (median). Mothers' addresses were linked to a statewide database of commercial applications to estimate agricultural pesticide exposure. Results: High FA intake (≥800 µg) during the first pregnancy month and no known pesticide exposure was the reference group for all analyses. Compared with this group, ASD was increased in association with <800 µg FA and any indoor pesticide exposure {adjusted odds ratio [OR]=2.5 [95% confidence interval (CI): 1.3, 4.7]} compared with low FA [OR=1.2 (95% CI: 0.7, 2.2)] or indoor pesticides [OR=1.7 (95% CI: 1.1, 2.8)] alone. ORs for the combination of low FA and regular pregnancy exposure (≥6 mo) to pet pesticides or to outdoor sprays and foggers were 3.9 (95% CI: 1.4, 11.5) and 4.1 (95% CI: 1.7, 10.1), respectively. ORs for low maternal FA and agricultural pesticide exposure 3 mo before or after conception were 2.2 (95% CI: 0.7, 6.5) for chlorpyrifos, 2.3 (95% CI: 0.98, 5.3) for organophosphates, 2.1 (95% CI: 0.9, 4.8) for pyrethroids, and 1.5 (95% CI: 0.5, 4.8) for carbamates. Except for carbamates, these ORs were approximately two times greater than those for either exposure alone or for the expected ORs for combined exposures under multiplicative or additive models. Conclusions: In this study population, associations between pesticide exposures and ASD were attenuated among those with high versus low FA intake during the first month of pregnancy. Confirmatory and mechanistic studies are needed. [Description provided by NIOSH]
• Subjects:
  Insecticides Occupational Health Pregnancy Safety
• Keywords:
  ASDs Autism Spectrum Disorders Pesticides Prenatal Exposure Vitamins
• ISSN:
  0091-6765
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  125
• Issue:
  9
• NIOSHTIC Number:
  nn:20050363
• Citation:
  Environ Health Perspect 2017 Sep; 125(9):097007
• Contact Point Address:
  R. J. Schmidt, 123 Medical Sciences 1C, One Shields Ave., Davis, CA 95616-8638, USA
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Health Perspectives
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a55a282a3050feb040854d002a59875699e40189e95463be5a9414f5745609c07d5a8f2788feceac4709dc5df5be6d2c21d40cc1cc8d3946e285883f49c319cd
• Download URL:
  https://stacks.cdc.gov/view/cdc/210742/cdc_210742_DS1.pdf
• File Type:
  [PDF - 914.84 KB ]