The Association of Prenatal Vitamins and Folic Acid Supplement Intake with Odds of Autism Spectrum Disorder in a High-Risk Sibling Cohort, the Early Autism Risk Longitudinal Investigation (EARLI)

Details

• Personal Author:
  Bakulski KM ; Baylin A ; Brieger KK ; Croen LA ; Dou JF ; Fallin MD ; Feinberg JI ; Hertz-Picciotto I ; Newschaffer CJ ; Pearce CL ; Schmidt RJ
• Description:
  We examined maternal prenatal vitamin use or supplemental folic acid intake during month one of pregnancy for association with autism spectrum disorder (ASD) in the Early Autism Risk Longitudinal Investigation, an enriched-risk pregnancy cohort. Total folic acid intake was calculated from monthly prenatal vitamins, multivitamins, and other supplement reports. Clinical assessments through age 3 years classified children as ASD (n = 38) or non-ASD (n = 153). In pregnancy month one, prenatal vitamin use (59.7%) was not significantly associated with odds of ASD (OR = 0.70, 95%CI 0.32, 1.53). Sample size was limited and residual confounding was possible. Given the estimated effect sizes in this and previous work, prenatal vitamin intake during early pregnancy could be a clinically useful preventative measure for ASD. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Epidemiology Genetics Occupational Health Pregnancy Safety
• Keywords:
  ASDs Author Keywords: Prenatal Vitamins Autism Autism Spectrum Disorders Cohort Studies Folic Acid Longitudinal Study Pregnancy Cohort Vitamins
• ISSN:
  0162-3257
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Maryland ; Michigan ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  52
• Issue:
  6
• NIOSHTIC Number:
  nn:20070650
• Citation:
  J Autism Dev Disord 2022 Jun; 52(6):2801-2811
• Contact Point Address:
  Kelly M. Bakulski, Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA
• Email:
  bakulski@umich.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Autism and Developmental Disorders
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:069fa7f822bb909892409e52e1d7dc1e3a3805d3ac8c779cb41d163cbba3dd40f36fc8f49c7795504595e9ec89b61b61f990f89fcf4adaf007cfb79c10e0895a
• Download URL:
  https://stacks.cdc.gov/view/cdc/208828/cdc_208828_DS1.pdf
• File Type:
  [PDF - 639.83 KB ]