Serum Perfluoroalkyl Substances and Cardiometabolic Consequences in Adolescents Exposed to the World Trade Center Disaster and a Matched Comparison Group

Details

• Personal Author:
  Attina TM ; Burdine LK ; Chu DB ; Ghassabian A ; Gilbert J ; Han X ; Honda M ; Kannan K ; Koshy TT ; Marmor M ; Shao Y ; Trasande L ; Urbina EM
• Description:
  Background: Large amounts of various chemical contaminants, including perfluoroalkyl substances (PFASs), were released at the time of the World Trade Center (WTC) disaster. Thousands of children who lived and/or attended school near the disaster site were exposed to these substances but few studies have examined the possible consequences related to these exposures. Objectives: To examine the relationship of PFASs serum levels with cardiometabolic profile in children and adolescents enrolled in the World Trade Center Health Registry (WTCHR) and a matched comparison group. Methods: We evaluated WTCHR enrollees who resided in New York City and were born between September 11, 1993 and September 10, 2001, and a matched comparison group consisting of individuals who were ineligible for WTCHR participation upon distance of their home, school or work from the WTC and lack of participation in rescue and recovery activities. Matching was based on date of birth, sex, race, ethnicity, and income. We assessed exposure to PFASs, as measured by serum levels and association with cardiometabolic profile as measured by arterial wall stiffness, body mass index, insulin resistance, fasting total cholesterol, HDL, LDL and triglycerides. Results: A total of 402 participants completed the study and serum samples were analyzed from 308 participants, 123 in the WTCHR group and 185 in the comparison group. In multivariable regression analysis, after adjusting for relevant confounders, we observed a significant, positive association of perfluorooctanoic acid (PFOA) with triglycerides (beta coefficient = 0.14, 95% CI: 0.02, 0.27, 15.1% change), total cholesterol (beta coefficient = 0.09, 95% CI: 0.04, 0.14, 9.2% change), and LDL cholesterol (beta coefficient = 0.11, 95% CI: 0.03, 0.19, 11.5% change). Perfluorohexanesulfonic acid levels were associated with decreased insulin resistance (beta coefficient = -0.09, 95% CI: -0.18, -0.003, -8.6% change); PFOA and perfluorononanoic acid were associated with increased brachial artery distensibility. Conclusions: This research adds to our knowledge of the physical health impacts in a large group of children exposed to the WTC disaster. Abnormal lipid levels in young adults might be an early marker of atherosclerosis and cardiovascular diseases and our findings highlight the importance of conducting longitudinal studies in this population. [Description provided by NIOSH]
• Subjects:
  Adolescent Cardiovascular Diseases Cardiovascular System Energy Metabolism Environmental Exposure Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Adolescents Author Keywords: Perfluoroalkyl Substances Cardiometabolic Consequences Cardiovascular Disease Children Disaster Sites Environmental Exposure Metabolic Effects Per- And Polyfluoroalkyl Substances PFAS World Trade Center World Trade Center Disaster WTC

  More +
• ISSN:
  0160-4120
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  128-135
• Volume:
  109
• NIOSHTIC Number:
  nn:20050332
• Citation:
  Environ Int 2017 Dec; 109:128-135
• Contact Point Address:
  Leonardo Trasande, Department of Pediatrics, New York University School of Medicine, 403 East 34th Street Rm 115, New York, NY 10016, USA
• Email:
  leonardo.trasande@nyumc.org
• CAS Registry Number:
  Perfluorohexanesulfonic acid (CAS RN 355-46-4) ; Perfluorononanoic acid (CAS RN 375-95-1) ; Perfluorooctanoic acid (CAS RN 335-67-1)
• Federal Fiscal Year:
  2018
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20130701
• Source Full Name:
  Environmental International
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a4ff324f704d397e3f24c7b5fa36023ba0c913c0c049943a5472f4434bbfbc1974d159788cee31753819a1420161df7207d1ea93aabc230ba85eab7252b34660
• Download URL:
  https://stacks.cdc.gov/view/cdc/210722/cdc_210722_DS1.pdf
• File Type:
  [PDF - 539.51 KB ]