Serum perfluoroalkyl substances in children exposed to the World Trade Center disaster

Details

• Personal Author:
  Attina TM ; Burdine LK ; Chu DB ; Ghassabian A ; Gilbert J ; Han X ; Honda M ; Kannan K ; Koshy TT ; Marmor M ; Shao Y ; Trasande L
• Description:
  The World Trade Center (WTC) disaster released large amounts of various chemical substances into the environment, including perfluoroalkyl substances (PFASs). Yet, no studies have examined exposures in children living or attending schools near the disaster site. We measured serum PFASs in WTC Health Registry (WTCHR) respondents who were >8 years of age on September 11, 2001 and a sociodemographically-matched comparison group. We also examined the relationship of PFASs levels with dust cloud exposure; home dust exposure, and with traumatic exposure, the latter to take into account differences related to possible mental health consequences and associated behavioral problems. Serum samples, collected between 2014 and 2016, were analyzed from 123 WTCHR participants and from 185 participants in the comparison group. In the WTCHR group, median perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) levels were 1.81 ng/mL and 3.72 ng/mL, respectively. Controlling for sex, caloric intake, race/ethnicity, and date of birth, significant increases among WTCHR participants compared with the matched comparison group were detected for perfluorohexanesulfonate (0.23 ng/mL increase or 0.24 log unit increase, p=0.006); PFOS (0.86 ng/mL increase or 0.16 log unit increase, p=0.011); PFOA (0.35 ng/mL increase or 0.18 log unit increase, p < 0.001); perfluorononanoic acid (0.12 ng/mL increase or 0.17 log unit increase, p=0.003); perfluorodecanoic acid (0.06 ng/mL increase or 0.42 log unit increase, p < 0.001); and perfluoroundecanoic acid (0.03 ng/mL increase or 0.32 log unit increase, p=0.019). Stronger associations were identified for home dust exposures and traumatic exposures than dust cloud. These findings highlight the importance of conducting longitudinal studies in this population to assess possible cardiometabolic and renal consequences related to these exposures. [Description provided by NIOSH]
• Subjects:
  Behavior Demography Dust Environmental Exposure Mental Disorders Mental Health Nervous System Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: Perfluoroalkyl Substances Behavioral Disorders Children Demographic Characteristics Disaster Sites Dust Cloud Dusts Environmental Exposure Home Dust Exposure Mental Health Per- And Polyfluoroalkyl Substances PFAS World Trade Center World Trade Center Disaster WTC

  More +
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  212-221
• Volume:
  154
• NIOSHTIC Number:
  nn:20049153
• Citation:
  Environ Res 2017 Apr; 154:212-221
• Contact Point Address:
  Leonardo Trasande, Department of Pediatrics, New York University School of Medicine, 403 East 34th Street Rm 115, New York, NY 10016
• Email:
  leonardo.trasande@nyumc.org
• CAS Registry Number:
  Perfluorooctanesulfonic acid (CAS RN 1763-23-1) ; Perfluorooctanoic acid (CAS RN 335-67-1)
• Federal Fiscal Year:
  2017
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20130701
• Source Full Name:
  Environmental Research
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7638ba7786f712133f383b988e98ace5d070c19ec8d9e16a945f2d2a8569da25ab26ddc637ada15cc7d3927bb5fabd5a5b29a165800ef31e1846f61e0f247e1c
• Download URL:
  https://stacks.cdc.gov/view/cdc/203705/cdc_203705_DS1.pdf
• File Type:
  [PDF - 804.78 KB ]