Differential Pulmonary Effects of Wintertime California and China Particulate Matter in Healthy Young Mice

Details

• Personal Author:
  Bein KJ ; Castañeda AR ; Fulgar CCB ; Li W ; Pham AK ; Pinkerton KE ; Smiley-Jewell SM ; Sun X ; Wei H ; Young DE ; Zhang Q
• Description:
  Airborne particulate matter (PM) is associated with adverse cardiorespiratory effects. To better understand source-orientated PM toxicity, a comparative study of the biological effects of fine PM (diameter≤2.5um, PM2.5) collected during the winter season from Shanxi Province, China, and the Central Valley, California, United States, was conducted. The overarching hypothesis for this study was to test whether the chemical composition of PM on an equal mass basis from two urban areas, one in China and one in California, can lead to significantly different effects of acute toxicity and inflammation in the lungs of healthy young mice. Male, 8-week old BALB/C mice received a single 50ug dose of vehicle, Taiyuan PM or Sacramento PM by oropharyngeal aspiration and were sacrificed 24h later. Bronchoalveolar lavage, ELISA and histopathology were performed along with chemical analysis of PM composition. Sacramento PM had a greater proportion of oxidized organic material, significantly increased neutrophil numbers and elevated CXCL-1 and TNF-a protein levels compared to the Taiyuan PM. The findings suggest that Sacramento PM2.5 was associated with a greater inflammatory response compared to that of Taiyuan PM2.5 that may be due to a higher oxidice. Male, 8-week old BALB/C mice received a single 50ug dose of vehicle, Taiyuan PM or Sacramento PM by oropharyngeal aspiration and were sacrificed 24h later. Bronchoalveolar lavage, ELISA and histopathology were performed along with chemical analysis of PM composition. Sacramento PM had a greater proportion of oxidized organic material, significantly increased neutrophil numbers and elevated CXCL-1 and TNF-a protein levels compared to the Taiyuan PM. The findings suggest that Sacramento PM2.5 was associated with a greater inflammatory response compared to that of Taiyuan PM2.5 that may be due to a higher oxidized state of organic carbon and copper content. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Energy Metabolism Hazardous Substances Laboratories Lung Occupational Health Particulate Matter Pathology Respiratory System Safety

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• Keywords:
  Airborne Particulates Air Pollution Author Keywords: Air Pollution Chemokines Cytokines Health Effects Inflammation Laboratory Animals Lung Function Metabolism Organic Compounds Respiratory Function Toxic Effects Toxins

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• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-8
• Volume:
  278
• NIOSHTIC Number:
  nn:20050304
• Citation:
  Toxicol Lett 2017 Aug; 278:1-8
• Contact Point Address:
  Kent E. Pinkerton, Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616
• Email:
  kepinkerton@ucdavis.edu
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Toxicology Letters
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:43f64e4957ab7c0a5c0b8ee61c9bb1cae2a5a4e32a36aefdecfc0d6438f00ffa3aa8c0f26a2a23b8de6e737a0561bf459ff3f48ca68ff25ae6291edf202c44af
• Download URL:
  https://stacks.cdc.gov/view/cdc/210712/cdc_210712_DS1.pdf
• File Type:
  [PDF - 811.10 KB ]