Naphthylamine, 2-

Details

• Personal Author:
  Hopf NB ; Talaska G
• Description:
  In the British rubber industry, the use of b-naphthylamine ended in 1949 and was mainly replaced by N-phenyl- 2-naphthylamine (PBNA), which contained 2NA (1-2%) as impurities up to the early 1960s until further purification steps were introduced (Weiss et al., 2007). The production of PBNA in the United States was terminated at the beginning of the 1980s but was still a key component in rubber mixtures from other parts of the world. In addition, antioxidants in the rubber industry such as PBNA and N,N0-di- 2-naphthyl-p-phenylenediamine have been shown to be metabolized to 2NA following absorption. However, the observed quantities of urinary 2NA in workers exceeded the exposure to 2NA impurity by factors between 50 and 400 and have yet to be explained. 2NA and other aromatic amines such as 4-aminobiphenyl are also produced during the burning of tobacco, especially low-temperature burning, and when cooking fats and oils are heated. Trace amounts of 2NA have been found in dye containing products such as children's finger paints. [Description provided by NIOSH]
• Subjects:
  Amines Antioxidants Chemistry Energy Metabolism Environmental Exposure Hazardous Substances Men Occupational Health Paint Risk Assessment Risk Factors Rubber Safety Smoke Tobacco Products Urine Women

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• Keywords:
  Acute Toxicity Aromatic Amines Author Keywords: Acetylation Chemical Properties Chemicals Chronic Toxicity CYP450 Dye Workers Exposure Levels Humans Metabolic Transformation Metabolism Paints Risk Factors Rubber Products Rubber Workers Tobacco Tobacco Smoke Urinalysis Urinary Bladder Cancer Workers

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• ISBN:
  9780123864543
• Publisher:
  Elsevier
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  440-443
• NIOSHTIC Number:
  nn:20050278
• Citation:
  Encyclopedia of toxicology, third edition. Wexler PE, ed. Oxford, UK: Elsevier, 2014 Sep; :440-443
• CAS Registry Number:
  2-Naphthylamine (CAS RN 91-59-8)
• Editor(s):
  Wexler PE
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Encyclopedia of toxicology, third edition
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4e8c6d5ae275fdcdd737a23b52ed0fe8c6e292ad6133c359e2602a43e9e210e19851ed1fce4c293076becda0038764ae1e2eb23aa754519e4322ad54a52717ae
• Download URL:
  https://stacks.cdc.gov/view/cdc/210696/cdc_210696_DS1.pdf
• File Type:
  [PDF - 85.22 KB ]