2-Naphthol Levels and Genotoxicity in Rubber Workers

Details

• Personal Author:
  Gaultney B ; Peters S ; Succop P ; Talaska G ; Vermeulen R
• Description:
  Urinary bladder cancer is a historical disease of rubber workers often been associated with exposure to aromatic amines such as 2-naphthylamine. While exposure to these compounds has decreased markedly over time, the bladder cancer risk has not decreased in direct proportion. Polycyclic aromatic compounds (PAC) are candidates for urinary bladder cancer causation. We determined pre- and post-exposure urinary levels of 2-napthol (2NAP), the major metabolite of a model volatile PAC, in a group of non-smoking rubber workers. Pre- and post-exposure urine samples were collected from 43 non-smoking workers. Overall mean post-shift 2-naphthol levels were increased (13.95 +/- 28.4 ug/l), but non-significantly compared to samples collected pre-exposure (7.97 +/- 22.1 ug/l; p=0.29). The greatest difference was observed in the curing department where post-exposure samples were 4.5 fold higher, post shift samples were significantly higher in production workers as compared to non-production workers (p=0.02). Levels of 2NAP were not correlated with levels of carcinogen-DNA adducts in exfoliated urothelial cells nor with other estimates of exposure or effect. These data suggest that post-shift urinary 2NAP levels are increased, particularly in the curing department. However, the differences were not significantly different overall and urinary 2NAP levels did not predict the level of carcinogen DNA adducts in exfoliated urothelial cells. [Description provided by NIOSH]
• Subjects:
  Amines Carcinogens Chemistry Energy Metabolism Environmental Exposure Neoplasms Occupational Health Risk Assessment Risk Factors Rubber Safety Urine Workplace

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• Keywords:
  Aromatic Amines Author Keywords: 2-Naphthol Biomonitoring Bladder Cancer Cancer Chemical Properties Diseases DNA Adducts Exposure Levels Metabolites Models Naphthylamines Risk Factors Rubber Workers Sampling Urinalysis Urinary Levels Urogenital System Disorders Urothelial Cells Work Environment Workers

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• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  45-48
• Volume:
  213
• Issue:
  1
• NIOSHTIC Number:
  nn:20050257
• Citation:
  Toxicol Lett 2012 Aug; 213(1):45-48
• Contact Point Address:
  Glenn Talaska, Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Ave, Cincinnati, OH 45267-0056
• Email:
  glenn.talaska@uc.edu
• CAS Registry Number:
  2-Naphthol (CAS RN 135-19-3) ; Benzo[a]pyrene (CAS RN 50-32-8)
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Toxicology Letters
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:707e6c6ea72277394e30ec46eb3501b9f2a98553b7779b2b70d22bede6c1a4841949658b0c66750eccc4c616aa37d9f4a8f131490754a6d9bd466dd4c165cdda
• Download URL:
  https://stacks.cdc.gov/view/cdc/210679/cdc_210679_DS1.pdf
• File Type:
  [PDF - 170.30 KB ]