Biomarkers of Polycyclic Aromatic Hydrocarbon Exposure in European Coke Oven Workers

Details

• Personal Author:
  Kafferlein HU ; Schuman B ; Talaska G ; Thoroman J
• Description:
  Biomonitoring is an excellent method for capturing the results of all exposures, regardless of route. Coke oven workers include certain groups that have the potential for high exposure to polycyclic aromatic hydrocarbons (PAH) and other materials. Biomarkers of exposure to these agents include PAH metabolites as markers of internal dose and carcinogen-DNA adducts as measure of effective dose. The purpose of this study was to determine the levels of these biomarkers in persons with different job duties in a modern coke oven plant. We report that the mean levels of 1-hydroxypyrene (1HP) and carcinogen DNA adducts in the exfoliated urothelial cells of coke oven workers are increased the closer a group of workers is to the ovens and highest in the top oven workers with average 1HP level of 11.6 µg/l and 22 adducts per 109 unadducted nucleotides. Both 1HP and carcinogen DNA adduct levels increased in supervisors, area workers, side oven workers, top and side oven workers, and top oven workers, respectively. These data are the first to demonstrate an increase in target organ genotoxicity in coke oven workers and a relationship with other biomarkers. Future studies will determine the identity of the DNA adducts, their correlation with 1HP levels and the relationship between levels in individual workers. [Description provided by NIOSH]
• Subjects:
  Biomarkers Carcinogens Energy Metabolism Environmental Exposure Occupational Health Risk Assessment Risk Factors Safety Workplace
• Keywords:
  1-Hydroxypyrene Author Keywords: Biomonitoring Biomonitoring Carcinogen-DNA Adduct Coke Manufacturing Coke Oven Emissions Coke Ovens Coke Oven Workers Exfoliated Urothelial Cells Exposure Levels Genotoxicity Metabolites Polycyclic Hydrocarbons Risk Factors Top Oven Workers Work Environment Workers

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• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  213-216
• Volume:
  231
• Issue:
  2
• NIOSHTIC Number:
  nn:20050092
• Citation:
  Toxicol Lett 2014 Dec; 231(2):213-216
• Contact Point Address:
  Glenn Talaska, Sandia National Laboratories, P.O. Box 5800, MS-1478, Albuquerque, NM 87185
• Email:
  glenn.talaska@uc.edu
• CAS Registry Number:
  1-Hydroxypyrene (CAS RN 5315-79-7)
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Toxicology Letters
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6b67a4b188cf6a6b856ac6be464f65bbf1fe972abcd18426ecf0f2e9fd64cdcec37743d268862610147aa83c5ad185c2b8adc243a490e898d24fa574def9c3a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/210592/cdc_210592_DS1.pdf
• File Type:
  [PDF - 802.78 KB ]