Interactions Between Occupational Exposure to Extremely Low Frequency Magnetic Fields and Chemicals for Brain Tumour Risk in the INTEROCC Study

Details

• Personal Author:
  Benke G ; Bowman, Joseph D. ; Cardis E ; Figuerola J ; Fleming S ; Hours M ; Kincl, Laurel ; Krewski D ; McLean D ; Parent M-E ; Richardson L ; Sadetzki S ; Schlaefer K ; Schlehofer B ; Schüz J ; Siemiatycki J ; Turner MC ; van Tongeren M
• Description:
  Objectives: In absence of clear evidence regarding possible effects of occupational chemical exposures on brain tumour aetiology, it is worthwhile to explore the hypothesis that such exposures might act on brain tumour risk in interaction with occupational exposure to extremely low frequency magnetic fields (ELF). Methods: INTEROCC is a seven-country (Australia, Canada, France, Germany, Israel, New Zealand and UK), population-based, case-control study, based on the larger INTERPHONE study. Incident cases of primary glioma and meningioma were ascertained from 2000 to 2004. Job titles were coded into standard international occupational classifications and estimates of ELF and chemical exposures were assigned based on job-exposure matrices. Dichotomous indicators of cumulative ELF (>/=50th vs <50th percentile, 1-4 year exposure time window) and chemical exposures (ever vs never, 5-year lag) were created. Interaction was assessed on both the additive and multiplicative scales. Results: A total of 1939 glioma cases, 1822 meningioma cases and 5404 controls were included in the analysis, using conditional logistic regression. There was no clear evidence for interactions between ELF and any of the chemical exposures assessed for either glioma or meningioma risk. For glioma, subjects in the low ELF/metal exposed group had a lower risk than would be predicted from marginal effects. Results were similar according to different exposure time windows, to cut-points of exposure or in exposed-only analyses. Conclusions: There was no clear evidence for interactions between occupational ELF and chemical exposures in relation to glioma or meningioma risk observed. Further research with more refined estimates of occupational exposures is recommended. [Description provided by NIOSH]
• Subjects:
  Electromagnetic Phenomena Environmental Exposure Environmental Monitoring Magnetic Fields Neoplasms Nervous System Nervous System Diseases Occupational Exposure Occupational Health Radiation Safety

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• Keywords:
  Brain-tumors Case Control Studies Chemical-deposition Chemical Agents Chemicals Electromagnetic-fields Employee Exposure Etiology Exposure-assessment Exposure Levels Ionizing-radiation JEM Job Analysis Job Exposure Matrix Magnetic-fields Magnetic-properties Occupational-exposure Population Based Studies

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; Oregon ; OSHA Region 10 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  74
• Issue:
  11
• NIOSHTIC Number:
  nn:20049900
• Citation:
  Occup Environ Med 2017 Nov; 74(11):802-809
• Contact Point Address:
  Dr Michelle C Turner, Barcelona Institute for Global Health (ISGlobal), Parc de Recerca Biomèdica de Barcelona, Barcelona 08003, Spain
• Email:
  michelle.turner@isglobal.org
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c439e2289f8fca09a20ab1e1afeb273b0f6973910a7f6bba518a574df2932f7d36081f1079630e2176fc7c74d9fba3af67a301efb50dadc7c697299fa8f7c01a
• Download URL:
  https://stacks.cdc.gov/view/cdc/210495/cdc_210495_DS1.pdf
• File Type:
  [PDF - 358.83 KB ]