Soluble and particulate activators of complement and granulomatous pulmonary reactions

Details

• Personal Author:
  Green FH ; Mentnech SM ; Pearson DJ
• Description:
  In order to test the hypothesis that the histological changes of extrinsic allergic alveolitis result from non-specific activation of the complement cascade we studied pulmonary reactions to equivalent doses of soluble and particulate activators of complement in rats. A single intratracheal instillation of zymosan, a particulate activator of the complement system, produced a florid granulomatous pneumonitis which was maximal at 5 days. This granulomatous reaction did not appear to be associated with the development of hypersensitivity to zymosan. Complement depletion by cobra venom factor did not suppress the granulomatous reaction. Equivalent doses of soluble activators of complement failed to produce any inflammatory changes in the lung. Large doses of immune complex produced an acute, complement dependent, haemorrhagic alveolitis which was maximal at 8 hr and which resolved completely by 48 hr. We conclude that the late granulomatous pulmonary reaction to intra-tracheally administered zymosan is not due to an immune response, or a consequence of direct activation of the alternative pathway of complement, but is of 'foreign body' type. We urge caution in drawing conclusions regarding the pathogenesis of the allergic alveolitides on histological appearances alone. [Description provided by NIOSH]
• Subjects:
  Animals Hypersensitivity Immune System Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Allergic-reactions Animal-studies Immunology Laboratory-animals Lung-disease Lung-disorders Lung-function Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  0009-9090
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  111-119
• Volume:
  11
• Issue:
  2
• NIOSHTIC Number:
  nn:20040960
• Citation:
  Clin Allergy 1981 Mar; 11(2):111-119
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  True
• Source Full Name:
  Clinical Allergy
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1c049f11770faf2c49a44065070c28b6484749467bad99b135c27a4552983e02e99ce3c6d40c6dfb5f02b023be86145ec5a2143da3385dfe331a20f651bfd10e
• Download URL:
  https://stacks.cdc.gov/view/cdc/193647/cdc_193647_DS1.pdf
• File Type:
  [PDF - 3.46 MB ]