Xenobiotic Particle Exposure and Microvascular Endpoints: A Call to Arms

Details

• Personal Author:
  Knuckles TL ; McCawley M ; Minarchick VC ; Nurkiewicz TR ; Stapleton PA
• Description:
  Xenobiotic particles can be considered in two genres: air pollution particulate matter and engineered nanoparticles. Particle exposures can occur in the greater environment, the workplace, and our homes. The majority of research in this field has, justifiably, focused on pulmonary reactions and outcomes. More recent investigations indicate that cardiovascular effects are capable of correlating with established mortality and morbidity epidemiological data following particle exposures. While the preliminary and general cardiovascular toxicology has been defined, the mechanisms behind these effects, specifically within the microcirculation, are largely unexplored. Therefore, the purpose of this review is several fold: first, a historical background on toxicological aspects of particle research is presented. Second, essential definitions, terminology, and techniques that may be unfamiliar to the microvascular scientist will be discussed. Third, the most current concepts and hypotheses driving cardiovascular research in this field will be reviewed. Lastly, potential future directions for the microvascular scientist will be suggested. Collectively speaking, microvascular research in the particle exposure field represents far more than a "niche." The immediate demand for basic, translational, and clinical studies is high and diverse. Microvascular scientists at all career stages are strongly encouraged to expand their research interests to include investigations associated with particle exposures. [Description provided by NIOSH]
• Subjects:
  Animals Cardiovascular Diseases Cardiovascular System Chemistry Engineering Environmental Exposure Epidemiology Lung Lung Diseases Morbidity Mortality Occupational Health Particulate Matter Pathology Respiratory System Respiratory Tract Diseases Safety Toxicology

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• Keywords:
  Author Keywords: Particulate Matter Cardiovascular Cardiovascular Disease Cardiovascular System Chemical Composition Chemical Properties Drugs Exposure Exposure Levels Health Effects Microcirculation Morbidity Rates Mortality Rates Nanoparticles Nanotechnology Particulates Physiology Pollution Pulmonary Effects Pulmonary System Pulmonary System Disorders Xenobiotics

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• ISSN:
  1073-9688
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  126-142
• Volume:
  19
• Issue:
  2
• NIOSHTIC Number:
  nn:20049532
• Citation:
  Microcirculation 2012 Feb; 19(2):126-142
• Contact Point Address:
  Timothy R. Nurkiewicz, Ph.D., Center for Cardiovascular and Respiratory Sciences, 1 Medical Center Drive, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506-9105
• Email:
  tnurkiewicz@hsc.wvu.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Microcirculation
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:911feade2417bc8a252b660e5e9a7335239eab39fbd0029b363faba9d638b75f6dd741b4737dd82875a95de6290e8784836d464c2da8577dbdcdee22275a4fcc
• Download URL:
  https://stacks.cdc.gov/view/cdc/210283/cdc_210283_DS1.pdf
• File Type:
  [PDF - 385.36 KB ]