NIOSH Skin Notation (SK) Profile: Dinitrotoluene; 2,4-Dinitrotoluene (2,4-DNT); 2,6-Dinitrotoluene (2,6-DNT)

Details

• Personal Author:
  Dotson, G. Scott
• Description:
  This Skin Notation Profile presents (1) brief summary of technical data associated with skin contact with DNT* and (2) the rationale behind the hazard-specific skin notation (SK) assignment for DNT. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to DNT. A literature search was conducted through July 2010 to identify information on DNT, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to DNT. DNT is potentially capable of causing numerous adverse health effects following skin contact. A critical review of available data has resulted in the following SK assignment for DNT: SK: SYS-DIR (IRR). Table 1 provides an overview of the critical effects and data used to develop the SK assignment for DNT. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chemistry Environmental Monitoring Hazardous Substances Hypersensitivity Immune System Occupational Health Safety Skin Skin Absorption Toluene Urogenital System

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• Keywords:
  Biological-effects Carcinogenicity Chemical-analysis Chemical-composition Chemical-kinetics Chemical-properties Chemical-reactions Chemical-structure Dermal-absorption Dermal-exposure Dermatology Developmental-disorders Dose-response Exposure-assessment Health-hazards Immunologic-disorders Kinetics Reproductive-effects Sensitization Skin-absorption Skin-exposure Skin-irritants Toluenes Toxic-dose Toxic-effects

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• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2011138
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division ; DART - Division of Applied Research and Technology ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-11
• NIOSHTIC Number:
  nn:20038772
• NTIS Accession Number:
  PB2017-102197
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2011-138, 2011 Apr; :1-11
• CAS Registry Number:
  2,4-Dinitrotoluene (CAS RN 121-14-2) ; 2,6-Dinitrotoluene (CAS RN 606-20-2) ; Dinitrotoluene (CAS RN 25321-14-6)
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Services
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:215efa821460bf2b2a5a644b594c053a49a8233f733e45281f4ddf6742066d1fef0a5e53da0caeac9a84da1f1edb45c0697a8c901ee4c47dc42c8fa21a12e590
• Download URL:
  https://stacks.cdc.gov/view/cdc/209968/cdc_209968_DS1.pdf
• File Type:
  [PDF - 653.32 KB ]