Severe Influenza-associated Respiratory Infection in High HIV Prevalence Setting, South Africa, 2009–2011

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Cohen, Cheryl ; Moyes, Jocelyn ; Tempia, Stefano ; Groom, Michelle ; Walaza, Sibongile ; Pretorius, Marthi ; Dawood, Halima ; Chhagan, Meera ; Haffejee, Summaya ; Variava, Ebrahim ; Kahn, Kathleen ; Tshangela, Akhona ; von Gottberg, Anne ; Wolter, Nicole ; Cohen, Adam L. ; Kgokong, Babatyi ; Venter, Marietjie ; Madhi, Shabir A.
• Description:
  Data on influenza epidemiology in HIV-infected persons are limited, particularly for sub-Saharan Africa, where HIV infection is widespread. We tested respiratory and blood samples from patients with acute lower respiratory tract infections hospitalized in South Africa during 2009-2011 for viral and pneumococcal infections. Influenza was identified in 9% (1,056/11,925) of patients enrolled; among influenza case-patients, 358 (44%) of the 819 who were tested were infected with HIV. Influenza-associated acute lower respiratory tract infection incidence was 4-8 times greater for HIV-infected (186-228/100,000) than for HIV-uninfected persons (26-54/100,000). Furthermore, multivariable analysis showed HIV-infected patients were more likely to have pneumococcal co-infection; to be infected with influenza type B compared with type A; to be hospitalized for 2-7 days or >7 days; and to die from their illness. These findings indicate that HIV-infected persons are at greater risk for severe illnesses related to influenza and thus should be prioritized for influenza vaccination.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Coinfection Female HIV Infections Hospitalization Humans Incidence Infant Infant, Newborn Influenza, Human Male Middle Aged Prevalence Prospective Studies Public Health Surveillance Research Respiratory Tract Infections Young Adult

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• Source:
  Emerg Infect Dis. 19(11):1766-1774.
• Document Type:
  Journal Article
• Place as Subject:
  South Africa
• Location:
  Africa
• Volume:
  19
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:98568203fb620c4d522df965d25a0d28d7118624aebbef64e8a8264c91bfda2e
• Download URL:
  https://stacks.cdc.gov/view/cdc/20977/cdc_20977_DS1.pdf
• File Type:
  [PDF - 678.37 KB ]