Details:

Alternative Title:
PLoS One
Personal Author:
Emukule, Gideon O. ; Namagambo, Barbara ; Owor, Nicholas ; Bakamutumaho, Barnabas ; Kayiwa, John T. ; ... More +
Emukule, Gideon O. ; Namagambo, Barbara ; Owor, Nicholas ; Bakamutumaho, Barnabas ; Kayiwa, John T. ; Namulondo, Joyce ; Byaruhanga, Timothy ; Tempia, Stefano ; Chaves, Sandra S. ; Lutwama, Julius J. Less -
Description:
Background

Influenza is an important contributor to acute respiratory illness, including pneumonia, and results in substantial morbidity and mortality globally. Understanding the local burden of influenza-associated severe disease can inform decisions on allocation of resources toward influenza control programs. Currently, there is no national influenza vaccination program in Uganda.

Methods

In this study, we used data on pneumonia hospitalizations that were collected and reported through the Health Management Information System (HMIS) of the Ministry of Health, Uganda, and the laboratory-confirmed influenza positivity data from severe acute respiratory illness (SARI) surveillance in three districts (Wakiso, Mbarara, and Tororo) to estimate the age-specific incidence of influenza-associated pneumonia hospitalizations from January 2013 through December 2016.

Results

The overall estimated mean annual rate of pneumonia hospitalizations in the three districts was 371 (95% confidence interval [CI] 323–434) per 100,000 persons, and was highest among children aged <5 years (1,524 [95% CI 1,286–1,849]) compared to persons aged ≥5 years (123 [95% CI 105–144]) per 100,000 persons. The estimated mean annual rate of influenza-associated pneumonia hospitalization was 34 (95% CI 23–48) per 100,000 persons (116 [95% CI 78–165] and 16 [95% CI 6–28] per 100,000 persons among children aged <5 years and those ≥5 years, respectively). Among children aged <5 years, the rate of hospitalized influenza-associated pneumonia was highest among those who were <2 years old (178 [95% CI 109–265] per 100,000 persons). Over the period of analysis, the estimated mean annual number of hospitalized influenza-associated pneumonia cases in the three districts ranged between 672 and 1,436, of which over 70% represent children aged <5 years.

Conclusions

The burden of influenza-associated pneumonia hospitalizations was substantial in Uganda, and was highest among young children aged <5 years. Influenza vaccination may be considered, especially for very young children.


Subjects:
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Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Epidemiological Monitoring Female Hospitalization Humans Infant Infant, Newborn Influenza, Human Male Middle Aged Pneumonia Young Adult
Source:
PLoS One. 14(7)
Pubmed ID:
31306466
Pubmed Central ID:
PMC6629074
Document Type:
Journal Article
Place as Subject:
Uganda
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:482e2e66c107ae6e6229f35646a8dbfb88f43c67cdfd94947a0116a41725b933
Download URL:
https://stacks.cdc.gov/view/cdc/82097/cdc_82097_DS1.pdf
File Type:

Supporting Files

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