Influenza-associated pneumonia hospitalizations in Uganda, 2013-2016

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Emukule, Gideon O. ; Namagambo, Barbara ; Owor, Nicholas ; Bakamutumaho, Barnabas ; Kayiwa, John T. ; Namulondo, Joyce ; Byaruhanga, Timothy ; Tempia, Stefano ; Chaves, Sandra S. ; Lutwama, Julius J.
• Description:
  Background
  
  Influenza is an important contributor to acute respiratory illness, including pneumonia, and results in substantial morbidity and mortality globally. Understanding the local burden of influenza-associated severe disease can inform decisions on allocation of resources toward influenza control programs. Currently, there is no national influenza vaccination program in Uganda.
  
  Methods
  
  In this study, we used data on pneumonia hospitalizations that were collected and reported through the Health Management Information System (HMIS) of the Ministry of Health, Uganda, and the laboratory-confirmed influenza positivity data from severe acute respiratory illness (SARI) surveillance in three districts (Wakiso, Mbarara, and Tororo) to estimate the age-specific incidence of influenza-associated pneumonia hospitalizations from January 2013 through December 2016.
  
  Results
  
  The overall estimated mean annual rate of pneumonia hospitalizations in the three districts was 371 (95% confidence interval [CI] 323–434) per 100,000 persons, and was highest among children aged <5 years (1,524 [95% CI 1,286–1,849]) compared to persons aged ≥5 years (123 [95% CI 105–144]) per 100,000 persons. The estimated mean annual rate of influenza-associated pneumonia hospitalization was 34 (95% CI 23–48) per 100,000 persons (116 [95% CI 78–165] and 16 [95% CI 6–28] per 100,000 persons among children aged <5 years and those ≥5 years, respectively). Among children aged <5 years, the rate of hospitalized influenza-associated pneumonia was highest among those who were <2 years old (178 [95% CI 109–265] per 100,000 persons). Over the period of analysis, the estimated mean annual number of hospitalized influenza-associated pneumonia cases in the three districts ranged between 672 and 1,436, of which over 70% represent children aged <5 years.
  
  Conclusions
  
  The burden of influenza-associated pneumonia hospitalizations was substantial in Uganda, and was highest among young children aged <5 years. Influenza vaccination may be considered, especially for very young children.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Epidemiological Monitoring Female Hospitalization Humans Infant Infant, Newborn Influenza, Human Male Middle Aged Pneumonia Young Adult

  More +
• Source:
  PLoS One. 14(7)
• Pubmed ID:
  31306466
• Pubmed Central ID:
  PMC6629074
• Document Type:
  Journal Article
• Place as Subject:
  Uganda
• Volume:
  14
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:482e2e66c107ae6e6229f35646a8dbfb88f43c67cdfd94947a0116a41725b933
• Download URL:
  https://stacks.cdc.gov/view/cdc/82097/cdc_82097_DS1.pdf
• File Type:
  [PDF - 1.63 MB ]