Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1911.130177
Personal Author:
An, Tong-Qing ; Peng, Jin-Mei ; Tian, Zhi-Jun ; Zhao, Hong-Yuan ; Li, Na ; ... More +
An, Tong-Qing ; Peng, Jin-Mei ; Tian, Zhi-Jun ; Zhao, Hong-Yuan ; Li, Na ; Liu, Yi-Min ; Chen, Jia-Zeng ; Leng, Chao-Liang ; Sun, Yan ; Chang, Dan ; Tong, Guang-Zhi Less -
Description:
The widely used pseudorabies virus (PRV) Bartha-K61 vaccine has played a key role in the eradication of PRV. Since late 2011, however, a disease characterized by neurologic symptoms and a high number of deaths among newborn piglets has occurred among Bartha-K61-vaccinated pigs on many farms in China. Clinical samples from pigs on 15 farms in 6 provinces were examined. The PRV gE gene was detectable by PCR in all samples, and sequence analysis of the gE gene showed that all isolates belonged to a relatively independent cluster and contained 2 amino acid insertions. A PRV (named HeN1) was isolated and caused transitional fever in pigs. In protection assays, Bartha-K61 vaccine provided 100% protection against lethal challenge with SC (a classical PRV) but only 50% protection against 4 challenges with strain HeN1. The findings suggest that Bartha-K61 vaccine does not provide effective protection against PRV HeN1 infection.
Subject:
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Animals Antibodies, Viral/immunology Herpesvirus 1, Suid Neutralization Tests Phylogeny Pseudorabies Pseudorabies Vaccines Research Swine Swine Diseases Vaccination Viral Envelope Proteins
Source:
Emerg Infect Dis. 19(11):1749-1755.
Document Type:
Journal Article
Place as Subject:
China
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:2db1d78b89b772fb0f4ecfc7dd159f4be500e2390dc46dfa4d66a9fa377ae190
Download URL:
https://stacks.cdc.gov/view/cdc/20968/cdc_20968_DS1.pdf
File Type:

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