Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1911.121470
Personal Author:
Wang, Guiqing ; Huang, Tiangui ; Surendraiah, Pavan Kumar Makam ; Wang, Kemeng ; Komal, Rashida ; ... More +
Wang, Guiqing ; Huang, Tiangui ; Surendraiah, Pavan Kumar Makam ; Wang, Kemeng ; Komal, Rashida ; Zhuge, Jian ; Chern, Chian-Ru ; Kryszuk, Alexander A. ; King, Cassidy ; Wormser, Gary P. ; Less -
Description:
CTX-M extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates are infrequently reported in the United States. In this study, we analyzed nonduplicate ESBL-producing K. pneumoniae and Escherichia coli clinical isolates collected during 2005-2012 at a tertiary care medical center in suburban New York City, USA, for the presence of blaCTX-M, blaSHV, blaTEM, and blaKPC genes. Despite a high prevalence of blaCTX-M genes in ESBL-producing E. coli since 2005, blaCTX-M genes were not detected in K. pneumoniae until 2009. The prevalence of CTX-M-producing K. pneumoniae increased significantly over time from 1.7% during 2005-2009 to 26.4% during 2010-2012 (p<0.0001). CTX-M-15 was the dominant CTX-M genotype. Pulsed-field gel electrophoresis and multilocus sequence typing revealed high genetic heterogeneities in CTX-M-producing K. pneumoniae isolates. This study demonstrates the recent emergence and polyclonal spread of multidrug resistant CTX-M-producing K. pneumoniae isolates among patients in a hospital setting in the United States.
Subject:
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Antimicrobial Resistance
Bacteria
Beta-lactamases CTX-M-15
Escherichia Coli
Extended-spectrum Beta-lactamases
Klebsiella Pneumoniae
Multilocus Sequence Typing
Pulsed-field Gel Electrophoresis
Research

Source:
Emerg Infect Dis. 19(11):1803-1810. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:359325aa87ce263b11192182a147cdf516a3294290c582eddc3be151112fbefb
File Type:

Supporting Files

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  	12-1470.nxml	txt
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