CTX-M β-Lactamase–producing Klebsiella pneumoniae in Suburban New York City, New York, USA

Wang, Guiqing; Huang, Tiangui; Surendraiah, Pavan Kumar Makam; Wang, Kemeng; Komal, Rashida; Zhuge, Jian; Chern, Chian-Ru; Kryszuk, Alexander A.; King, Cassidy; Wormser, Gary P.

doi:10.3201/eid1911.121470

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

CTX-M β-Lactamase–producing Klebsiella pneumoniae in Suburban New York City, New York, USA

Published Date:

Nov 2013

Publisher's site:

http://dx.doi.org/10.3201/eid1911.121470 New Site Icon

Source:

Emerg Infect Dis. 19(11):1803-1810.

[PDF-530.88 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Wang, Guiqing ; Huang, Tiangui ; Surendraiah, Pavan Kumar Makam ; Wang, Kemeng ; Komal, Rashida ; ... More ▼

Description:

CTX-M extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates are infrequently reported in the United States. In this study, we analyzed nonduplicate ESBL-producing K. pneumoniae and Escherichia coli clinical isolates collected during 2005-2012 at a tertiary care medical center in suburban New York City, USA, for the presence of blaCTX-M, blaSHV, blaTEM, and blaKPC genes. Despite a high prevalence of blaCTX-M genes in ESBL-producing E. coli since 2005, blaCTX-M genes were not detected in K. pneumoniae until 2009. The prevalence of CTX-M-producing K. pneumoniae increased significantly over time from 1.7% during 2005-2009 to 26.4% during 2010-2012 (p<0.0001). CTX-M-15 was the dominant CTX-M genotype. Pulsed-field gel electrophoresis and multilocus sequence typing revealed high genetic heterogeneities in CTX-M-producing K. pneumoniae isolates. This study demonstrates the recent emergence and polyclonal spread of multidrug resistant CTX-M-producing K. pneumoniae isolates among patients in a hospital setting in the United States.

Subject:

[+]

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	12-1470-F1.gif	image/gif
	12-1470-F1.jpg	image/jpeg
	12-1470-F2.gif	image/gif
	12-1470-F2.jpg	image/jpeg
	12-1470.nxml	text/plain
	license.txt	text/plain

No Related Documents.

You May Also Like:

Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase blaKPC-2 Gene1

Personal Author:

Cuzon, Gaëlle; Naas, Thierry; Truong, HaVy; Villegas, Maria-Virginia; Wisell, Karin T.; Carmeli, Yehuda; Gales, Ana. C.; Navon-Venezia, Shiri; Quinn, John P.; Nordmann, Patrice;

Published Date:

Sep 2010

Source:

Emerg Infect Dis. 16(9):1349-1356.

Description:

Klebsiella pneumoniaeisolates that produce carbapenemases (KPCs) are rapidly disseminating worldwide. To determine their genetic background, we investigated 16 blaKPC-2-harboring K. pneumoniae isolates from 5 countries. The isolates were multidrug re...

File Type:

[PDF - 379.30 KB]
Phenotypic and Genotypic Characterization of Enterobacteriaceae Producing Oxacillinase-48–Like Carbapenemases, United States

Personal Author:

Lutgring, Joseph D.; Zhu, Wenming; de Man, Tom J.B.; Avillan, Johannetsy J.; Anderson, Karen F.; Lonsway, David R.; Rowe, Lori A.; Batra, Dhwani; Rasheed, J. Kamile; Limbago, Brandi M.;

Published Date:

Apr 2018

Source:

Emerg Infect Dis. 24(4):700-709.

Description:

Oxacillinase (OXA)-48-like carbapenemases remain relatively uncommon in the United States. We performed phenotypic and genotypic characterization of 30 Enterobacteriaceae producing OXA-48-like carbapenemases that were recovered from patients during 2...

File Type:

[PDF - 1.02 MB]
Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan

Personal Author:

Yu, Wen Leong; Pfaller, Michael A.; Winokur, Patricia L.; Jones, Ronald N.;

Published Date:

May 2002

Source:

Emerg Infect Dis. 8(5):522-524.

Description:

To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum beta-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patt...

File Type:

[PDF - 155.12 KB]
Extended-Spectrum β-Lactamase–producing Enterobacteriaceae among Travelers from the Netherlands

Personal Author:

Paltansing, Sunita; Vlot, Jessica A.; Kraakman, Margriet E.M.; Mesman, Romy; Bruijning, Marguerite L.; Bernards, Alexandra T.; Visser, Leo G.; Veldkamp, Karin Ellen;

Published Date:

Aug 2013

Source:

Emerg Infect Dis. 19(8):1206-1213.

Description:

A prospective cohort study was performed among travelers from the Netherlands to investigate the acquisition of carbapenemase-producing Enterobacteriaceae (CP-E) and extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) and associated ...

File Type:

[PDF - 497.34 KB]
KPC Type β-Lactamase, Rural Pennsylvania

Personal Author:

Pope, Jonathan; Adams, Jennifer; Doi, Yohei; Szabo, Dora; Paterson, David L.;

Published Date:

Oct 2006

Source:

Emerg Infect Dis. 12(10):1613-1614.

File Type:

[PDF - 25.52 KB]