Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1911.121356
Personal Author:
Fenollar, Florence ; Célard, Marie ; Lagier, Jean-Christophe ; Lepidi, Hubert ; Fournier, Pierre-Edouard ; ... More +
Fenollar, Florence ; Célard, Marie ; Lagier, Jean-Christophe ; Lepidi, Hubert ; Fournier, Pierre-Edouard ; Raoult, Didier Less -
Description:
Tropheryma whipplei endocarditis differs from classic Whipple disease, which primarily affects the gastrointestinal system. We diagnosed 28 cases of T. whipplei endocarditis in Marseille, France, and compared them with cases reported in the literature. Specimens were analyzed mostly by molecular and histologic techniques. Duke criteria were ineffective for diagnosis before heart valve analysis. The disease occurred in men 40-80 years of age, of whom 21 (75%) had arthralgia (75%); 9 (32%) had valvular disease and 11 (39%) had fever. Clinical manifestations were predominantly cardiologic. Treatment with doxycycline and hydroxychloroquine for at least 12 months was successful. The cases we diagnosed differed from those reported from Germany, in which arthralgias were less common and previous valve lesions more common. A strong geographic specificity for this disease is found mainly in eastern-central France, Switzerland, and Germany. T. whipplei endocarditis is an emerging clinical entity observed in middle-aged and older men with arthralgia.
Subject:
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Arthralgia Bacteria Endocarditis Synopsis Tropheryma Whipplei Whipple Disease Whipple’s Disease
Source:
Emerg Infect Dis. 19(11):1721-1730.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:eb9639b7edb5e1d9714cd625f018097d9168a4181cfb660cb43dd807dd4e9e8f
Download URL:
https://stacks.cdc.gov/view/cdc/20960/cdc_20960_DS1.pdf
File Type:

Supporting Files

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