Cryptococcus gattii Infections in Multiple States Outside the US Pacific Northwest

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Harris, Julie R. ; Lockhart, Shawn R. ; Sondermeyer, Gail ; Vugia, Duc J. ; Crist, Matthew B. ; D’Angelo, Melissa Tobin ; Sellers, Brenda ; Franco-Paredes, Carlos ; Makvandi, Monear ; Smelser, Chad ; Greene, John ; Stanek, Danielle ; Signs, Kimberly ; Nett, Randall J. ; Chiller, Tom ; Park, Benjamin J.
• Description:
  Clonal VGII subtypes (outbreak strains) of Cryptococcus gattii have caused an outbreak in the US Pacific Northwest since 2004. Outbreak-associated infections occur equally in male and female patients (median age 56 years) and usually cause pulmonary disease in persons with underlying medical conditions. Since 2009, a total of 25 C. gattii infections, 23 (92%) caused by non-outbreak strain C. gattii, have been reported from 8 non-Pacific Northwest states. Sixteen (64%) patients were previously healthy, and 21 (84%) were male; median age was 43 years (range 15-83 years). Ten patients who provided information reported no past-year travel to areas where C. gattii is known to be endemic. Nineteen (76%) patients had central nervous system infections; 6 (24%) died. C. gattii infection in persons without exposure to known disease-endemic areas suggests possible endemicity in the United States outside the outbreak-affected region; these infections appear to differ in clinical and demographic characteristics from outbreak-associated C. gattii. Clinicians outside the outbreak-affected areas should be aware of locally acquired C. gattii infection and its varied signs and symptoms.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over CME Cryptococcosis Cryptococcus Gattii Disease Outbreaks Female Genotype Humans Lung Diseases, Fungal Male Middle Aged Phylogeny Young Adult

  More +
• Source:
  Emerg Infect Dis. 19(10):1621-1627.
• Document Type:
  Journal Article
• Place as Subject:
  Northwestern United States
• Location:
  North America
• Volume:
  19
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a75f4f8d6de69184910af427bee3dcafd7464935a68d8c83e84b2254d970cc77
• Download URL:
  https://stacks.cdc.gov/view/cdc/20937/cdc_20937_DS1.pdf
• File Type:
  [PDF - 890.79 KB ]