Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Harris, Julie R. ; Lockhart, Shawn R. ; Sondermeyer, Gail ; Vugia, Duc J. ; Crist, Matthew B. ; ... More +
Harris, Julie R. ; Lockhart, Shawn R. ; Sondermeyer, Gail ; Vugia, Duc J. ; Crist, Matthew B. ; D’Angelo, Melissa Tobin ; Sellers, Brenda ; Franco-Paredes, Carlos ; Makvandi, Monear ; Smelser, Chad ; Greene, John ; Stanek, Danielle ; Signs, Kimberly ; Nett, Randall J. ; Chiller, Tom ; Park, Benjamin J. Less -
Description:
Clonal VGII subtypes (outbreak strains) of Cryptococcus gattii have caused an outbreak in the US Pacific Northwest since 2004. Outbreak-associated infections occur equally in male and female patients (median age 56 years) and usually cause pulmonary disease in persons with underlying medical conditions. Since 2009, a total of 25 C. gattii infections, 23 (92%) caused by non-outbreak strain C. gattii, have been reported from 8 non-Pacific Northwest states. Sixteen (64%) patients were previously healthy, and 21 (84%) were male; median age was 43 years (range 15-83 years). Ten patients who provided information reported no past-year travel to areas where C. gattii is known to be endemic. Nineteen (76%) patients had central nervous system infections; 6 (24%) died. C. gattii infection in persons without exposure to known disease-endemic areas suggests possible endemicity in the United States outside the outbreak-affected region; these infections appear to differ in clinical and demographic characteristics from outbreak-associated C. gattii. Clinicians outside the outbreak-affected areas should be aware of locally acquired C. gattii infection and its varied signs and symptoms.
Subject:
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Adolescent
Adult
Aged
Aged, 80 And Over
CME
Cryptococcosis
Cryptococcus Gattii
Disease Outbreaks
Female
Genotype
Humans
Lung Diseases, Fungal
Male
Middle Aged
Phylogeny
Young Adult

Source:
Emerg Infect Dis. 19(10):1621-1627.
Document Type:
Journal Article
Place as Subject:
Northwestern United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:a75f4f8d6de69184910af427bee3dcafd7464935a68d8c83e84b2254d970cc77
File Type:

Supporting Files

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