Behavioral and Neurological Effects of Carbon Disulfide

Details

• Personal Author:
  Grether CB ; Tuttle TC ; Wood GD
• Description:
  The purpose of this investigation was to develop and apply a behavioral/neurological battery of tests to a sample of workers occupationally exposed to carbon-disulfide (75150). The neurological component of the investigation consisted of electro- diagnostic examinations of electromyograms, nerve conduction velocities, and a medical evaluation by a neurologist. Workers were also given psychometric tests of reaction time, coordination, visual search, short-term memory, and visual acuity. One hundred workers engaged in the manufacture of viscose rayon constituted the carbon- disulfide exposed group. Fifty workers engaged in similar work, but not occupationally exposed to carbon-disulfide, served as a control group. Since ambient air levels of carbon-disulfide could not be obtained within the viscose rayon plant, estimates of workers' exposure to carbon-disulfide were based on 1) detailed work history interviews with participants and 2) results from an iodine azide test for urine metabolites of carbon-disulfide. Based upon application of Allen's procedure of using a total neurologic score for assessment of peripheral neuropathy, 13 percent of the carbon- disulfide exposed workers showed a probable or definite polyneuropathy. After correcting for age effects, neurologic indicators or ulnar nerve damage was found to significantly correlate with indices of carbon-disulfide exposure, as did behavioral tests of reaction time dexterity, rate of visual search, and perceptual organization. (Contract No. 099-73-0035) [Description provided by NIOSH]
• Subjects:
  Behavior Energy Metabolism Mental Disorders Mental Health Nervous System Nervous System Diseases Occupational Health Safety Sense Organs Urine
• Keywords:
  Brain-disorders Contract-099-73-0035 Mental-disorders Mental-processes Metabolism Nervous-system-disorders Neurological-disorders NIOSH-Contract Perceptual-disorders Perceptual-distortion Physiological-factors Psychomotor-function Sensory-perceptual-disorders Urinalysis Urine-tests

  More +
• Series:
  NIOSH Numbered Publications
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-166
• NIOSHTIC Number:
  nn:00069067
• NTIS Accession Number:
  PB-274764
• Citation:
  Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 77-128, 1976 Dec; :1-166
• CAS Registry Number:
  Carbon disulfide (CAS RN 75-15-0)
• Federal Fiscal Year:
  1977
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8a5cacd681277651c8c04232f89206d11e4f40586eddc49b002aa7ae1cf21b9f2b41ad297219ffec567cacb2952866b4760931fdcf9171a5510787619d8978f2
• Download URL:
  https://stacks.cdc.gov/view/cdc/209263/cdc_209263_DS1.pdf
• File Type:
  [PDF - 5.43 MB ]