Antibody Responses against Pneumocystis jirovecii in Health Care Workers Over Time

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Fong, Serena ; Daly, Kieran R. ; Tipirneni, Renuka ; Jarlsberg, Leah G. ; Djawe, Kpandja ; Koch, Judy V. ; Swartzman, Alexandra ; Roth, Brenna ; Walzer, Peter D. ; Huang, Laurence
• Description:
  In a previous cross-sectional study, we showed that clinical staff working in a hospital had significantly higher antibody levels than nonclinical staff to Pneumocystis jirovecii. We conducted a longitudinal study, described here, to determine whether occupation and self-reported exposure to a patient with P. jirovecii pneumonia were associated with antibody levels to P. jirovecii over time. Baseline and quarterly serum specimens were collected and analyzed by using an ELISA that targeted different variants of the Pneumocystis major surface glycoprotein (MsgA, MsgB, MsgC1, MsgC3, MsgC8, and MsgC9). Clinical staff had significantly higher estimated geometric mean antibody levels against MsgC1 and MsgC8 than did nonclinical staff over time. Significant differences were observed when we compared the change in antibody levels to the different MsgC variants for staff who were and were not exposed to P. jirovecii pneumonia-infected patients. MsgC variants may serve as indicators of exposure to P. jirovecii in immunocompetent persons.
• Subjects:
  Fungi Health Care Worker–patient HIV HIV/AIDS And Other Retroviruses Human Immunodeficiency Virus Major Surface Glycoprotein Pneumocystis Jirovecii Pneumonia Research Respiratory Diseases Transmission

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• Source:
  Emerg Infect Dis. 19(10):1613-1620.
• Document Type:
  Journal Article
• Volume:
  19
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d267108ddcfd3b12e62bb4c9b37abe37547d8e69822022c2b2016e5df0bd983f
• Download URL:
  https://stacks.cdc.gov/view/cdc/20921/cdc_20921_DS1.pdf
• File Type:
  [PDF - 648.86 KB ]