Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Gehre, Florian ; Antonio, Martin ; Otu, Jacob K. ; Sallah, Neneh ; Secka, Oumie ; ... More +
Gehre, Florian ; Antonio, Martin ; Otu, Jacob K. ; Sallah, Neneh ; Secka, Oumie ; Faal, Tutty ; Owiafe, Patrick ; Sutherland, Jayne S. ; Adetifa, Ifedayo M. ; Ota, Martin O. ; Kampmann, Beate ; Corrah, Tumani ; de Jong, Bouke C. Less -
Description:
In West Africa, Mycobacterium tuberculosis strains co-circulate with M. africanum, and both pathogens cause pulmonary tuberculosis in humans. Given recent findings that M. tuberculosis T-cell epitopes are hyperconserved, we hypothesized that more immunogenic strains have increased capacity to spread within the human host population. We investigated the relationship between the composition of the mycobacterial population in The Gambia, as measured by spoligotype analysis, and the immunogenicity of these strains as measured by purified protein derivative-induced interferon-γ release in ELISPOT assays of peripheral blood mononuclear cells. We found a positive correlation between strains with superior spreading capacity and their relative immunogenicity. Although our observation is true for M. tuberculosis and M. africanum strains, the association was especially pronounced in 1 M. africanum sublineage, characterized by spoligotype shared international type 181, which is responsible for 20% of all tuberculosis cases in the region and therefore poses a major public health threat in The Gambia.
Subject:
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ELISPOT
Human Hosts
Immunogenicity
Mycobacterium Africanum
Mycobacterium Tuberculosis
Population Structure
PPD
Research
Shared International Type
SIT
Spoligotyping
The Gambia
Transmission
Tuberculosis And Other Mycobacteria

Source:
Emerg Infect Dis. 19(10):1593-1604.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:6e69b16ca8aa7cd7912342cf614284e73b5add98dc973694859bc67b0071efb9
File Type:

Supporting Files

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  	12-1023-Techapp-s1.pdf	pdf
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